Ai Y - Search Results

1

Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.

Cheng H, Linhares BM, Yu W, Cardenas MG, Ai Y, Jiang W, Winkler A, Cohen S, Melnick A, MacKerell A Jr, Cierpicki T, Xue F. Cheng H, et al. Among authors: ai y. J Med Chem. 2018 Sep 13;61(17):7573-7588. doi: 10.1021/acs.jmedchem.8b00040. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 29969259 Free PMC article.

2

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.

Ai Y, Hwang L, MacKerell AD Jr, Melnick A, Xue F. Ai Y, et al. J Med Chem. 2021 Apr 22;64(8):4333-4358. doi: 10.1021/acs.jmedchem.0c01686. Epub 2021 Apr 12. J Med Chem. 2021. PMID: 33844535 Free PMC article.

3

Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.

Obianom ON, Ai Y, Li Y, Yang W, Guo D, Yang H, Sakamuru S, Xia M, Xue F, Shu Y. Obianom ON, et al. Among authors: ai y. J Med Chem. 2019 Jan 24;62(2):727-741. doi: 10.1021/acs.jmedchem.8b01408. Epub 2019 Jan 10. J Med Chem. 2019. PMID: 30605343 Free PMC article.

4

Nitrogen Mustards as Anticancer Chemotherapies: Historic Perspective, Current Developments and Future Trends.

Diethelm-Varela B, Ai Y, Liang D, Xue F. Diethelm-Varela B, et al. Among authors: ai y. Curr Top Med Chem. 2019;19(9):691-712. doi: 10.2174/1568026619666190401100519. Curr Top Med Chem. 2019. PMID: 30931858 Review.

5

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation.

Yang W, Li Y, Ai Y, Obianom ON, Guo D, Yang H, Sakamuru S, Xia M, Shu Y, Xue F. Yang W, et al. Among authors: ai y. J Med Chem. 2019 Dec 26;62(24):11151-11164. doi: 10.1021/acs.jmedchem.9b01252. Epub 2019 Dec 10. J Med Chem. 2019. PMID: 31769984

6

Improving the solubility and antileukemia activity of Wnt/β-catenin signaling inhibitors by disrupting molecular planarity.

Ai Y, Sakamuru S, Imler G, Xia M, Xue F. Ai Y, et al. Bioorg Med Chem. 2022 Sep 1;69:116890. doi: 10.1016/j.bmc.2022.116890. Epub 2022 Jun 20. Bioorg Med Chem. 2022. PMID: 35777269 Free PMC article.

7

Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach.

Ai Y, Obianom ON, Kuser M, Li Y, Shu Y, Xue F. Ai Y, et al. ACS Med Chem Lett. 2018 Dec 3;10(1):127-131. doi: 10.1021/acsmedchemlett.8b00539. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655959 Free PMC article.

8

Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.

Liang D, Li L, Lynch C, Mackowiak B, Hedrich WD, Ai Y, Yin Y, Heyward S, Xia M, Wang H, Xue F. Liang D, et al. Among authors: ai y. Eur J Med Chem. 2019 Oct 1;179:84-99. doi: 10.1016/j.ejmech.2019.06.031. Epub 2019 Jun 15. Eur J Med Chem. 2019. PMID: 31247375 Free PMC article.

9

BCL6 BTB-specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta).

Cai Y, Watkins MA, Xue F, Ai Y, Cheng H, Midkiff CC, Wang X, Alvarez X, Poli ANR, Salvino JM, Veazey RS, Montaner LJ. Cai Y, et al. Among authors: ai y. J Med Primatol. 2020 Feb;49(1):26-33. doi: 10.1111/jmp.12438. Epub 2019 Oct 1. J Med Primatol. 2020. PMID: 31571234 Free PMC article.

10

Gallium(III)-Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition.

Centola G, Deredge DJ, Hom K, Ai Y, Dent AT, Xue F, Wilks A. Centola G, et al. Among authors: ai y. ACS Infect Dis. 2020 Aug 14;6(8):2073-2085. doi: 10.1021/acsinfecdis.0c00138. Epub 2020 Jul 6. ACS Infect Dis. 2020. PMID: 32551497 Free PMC article.

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