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Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.
Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN. Strangward P, et al. Among authors: couper kn. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7404-7409. doi: 10.1073/pnas.1801737115. Epub 2018 Jun 28. Proc Natl Acad Sci U S A. 2018. PMID: 29954866 Free PMC article.
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
Villegas-Mendez A, de Souza JB, Lavelle SW, Gwyer Findlay E, Shaw TN, van Rooijen N, Saris CJ, Hunter CA, Riley EM, Couper KN. Villegas-Mendez A, et al. Among authors: couper kn. PLoS Pathog. 2013;9(4):e1003293. doi: 10.1371/journal.ppat.1003293. Epub 2013 Apr 11. PLoS Pathog. 2013. PMID: 23593003 Free PMC article.
Parasite-Specific CD4+ IFN-γ+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection.
Villegas-Mendez A, Shaw TN, Inkson CA, Strangward P, de Souza JB, Couper KN. Villegas-Mendez A, et al. Among authors: couper kn. Infect Immun. 2015 Oct 12;84(1):34-46. doi: 10.1128/IAI.01100-15. Print 2016 Jan. Infect Immun. 2015. PMID: 26459508 Free PMC article.
Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.
Shaw TN, Stewart-Hutchinson PJ, Strangward P, Dandamudi DB, Coles JA, Villegas-Mendez A, Gallego-Delgado J, van Rooijen N, Zindy E, Rodriguez A, Brewer JM, Couper KN, Dustin ML. Shaw TN, et al. Among authors: couper kn. PLoS Pathog. 2015 Nov 12;11(11):e1005210. doi: 10.1371/journal.ppat.1005210. eCollection 2015. PLoS Pathog. 2015. PMID: 26562533 Free PMC article.
49 results