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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.
Mhlekude B, Postmus D, Stenzel S, Weiner J 3rd, Jansen J, Zapatero-Belinchón FJ, Olmer R, Richter A, Heinze J, Heinemann N, Mühlemann B, Schroeder S, Jones TC, Müller MA, Drosten C, Pich A, Thiel V, Martin U, Niemeyer D, Gerold G, Beule D, Goffinet C. Mhlekude B, et al. Among authors: gerold g. PLoS Pathog. 2023 Sep 25;19(9):e1011657. doi: 10.1371/journal.ppat.1011657. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747932 Free PMC article.
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.
Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen T-T, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T. Haid S, et al. Among authors: gerold g. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0121023. doi: 10.1128/aac.01210-23. Epub 2024 Feb 6. Antimicrob Agents Chemother. 2024. PMID: 38319076 Free PMC article.
Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons.
Passos V, Henkel LM, Wang J, Zapatero-Belinchón FJ, Möller R, Sun G, Waltl I, Schneider T, Wachs A, Ritter B, Kropp KA, Zhu S, Deleidi M, Kalinke U, Schulz TF, Höglinger G, Gerold G, Wegner F, Viejo-Borbolla A. Passos V, et al. Among authors: gerold g. J Med Virol. 2024 Feb;96(2):e29455. doi: 10.1002/jmv.29455. J Med Virol. 2024. PMID: 38323709
70 results