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Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers.
Vaswani RG, Huang DS, Anthony N, Xu L, Centore R, Schiller S, Li Z, Fan H, Setser J, Zawadzke LE, Davenport Y, Chen X, Barnash K, Adam A, Ichikawa K, Huang L, Gu CH, Voigt J, Millan D, Chan HM, Decicco C, Hentemann M, Bellon SF, Wilson KJ. Vaswani RG, et al. Among authors: wilson kj. J Med Chem. 2025 Jan 23;68(2):1772-1792. doi: 10.1021/acs.jmedchem.4c02535. Epub 2025 Jan 12. J Med Chem. 2025. PMID: 39801091
Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections.
Mandecki W, Chudaev M, Ye W, Wang AQ, Wilson KJ, Xu X, Kim J, Parker D, Alland D, Kumar P, Li B, Yang JH, Kreiswirth B, Mediavilla JR, Marugan JJ, Henderson MJ, Goldman E. Mandecki W, et al. Among authors: wilson kj. Appl Environ Microbiol. 2024 Dec 23:e0204624. doi: 10.1128/aem.02046-24. Online ahead of print. Appl Environ Microbiol. 2024. PMID: 39714192 Free article.
241 results