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Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair.
Ruffin M, Bilodeau C, Maillé É, LaFayette SL, McKay GA, Trinh NT, Beaudoin T, Desrosiers MY, Rousseau S, Nguyen D, Brochiero E. Ruffin M, et al. FASEB J. 2016 Sep;30(9):3011-25. doi: 10.1096/fj.201500166R. Epub 2016 May 13. FASEB J. 2016. PMID: 27178322 Free PMC article.
These data demonstrate that secreted proteases under the control of the LasR QS system impair airway epithelial repair and that QS inhibitors could be of benefit to counteract the deleterious effect of P. aeruginosa in infected patients.-Ruffin, M., Bilodeau, C., Ma …
These data demonstrate that secreted proteases under the control of the LasR QS system impair airway epithelial repair and that QS inhibitor …
Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells.
Maillé É, Ruffin M, Adam D, Messaoud H, Lafayette SL, McKay G, Nguyen D, Brochiero E. Maillé É, et al. Among authors: ruffin m. Front Cell Infect Microbiol. 2017 Nov 10;7:470. doi: 10.3389/fcimb.2017.00470. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 29177135 Free PMC article.
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM. Le Gars M, et al. Among authors: ruffin m. Am J Respir Crit Care Med. 2013 Jan 15;187(2):170-9. doi: 10.1164/rccm.201205-0875OC. Epub 2012 Dec 6. Am J Respir Crit Care Med. 2013. PMID: 23220915
305 results