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Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Hitzel J, et al. Among authors: kroll j. Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0. Nat Commun. 2018. PMID: 29895827 Free PMC article.
The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.
Schäker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J. Schäker K, et al. Among authors: kroll j. J Biol Chem. 2015 Mar 6;290(10):6408-18. doi: 10.1074/jbc.M114.633701. Epub 2015 Jan 13. J Biol Chem. 2015. PMID: 25586182 Free PMC article.
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk N, Morgenstern J, Fleming T, Nawroth PP, Kroll J. Schmöhl F, et al. Among authors: kroll j. Cell Mol Life Sci. 2019 Nov;76(22):4551-4568. doi: 10.1007/s00018-019-03127-z. Epub 2019 May 9. Cell Mol Life Sci. 2019. PMID: 31073745 Free PMC article.
Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease.
Qian X, Klatt S, Bennewitz K, Wohlfart DP, Lou B, Meng Y, Buettner M, Poschet G, Morgenstern J, Fleming T, Sticht C, Hausser I, Fleming I, Szendroedi J, Nawroth PP, Kroll J. Qian X, et al. Among authors: kroll j. Adv Sci (Weinh). 2024 Jan;11(4):e2302325. doi: 10.1002/advs.202302325. Epub 2023 Dec 7. Adv Sci (Weinh). 2024. PMID: 38059818 Free PMC article.
1,372 results