Brearley CA - Search Results

1

Simple synthesis of ³²P-labelled inositol hexakisphosphates for study of phosphate transformations.

Whitfield H, Riley AM, Diogenous S, Godage HY, Potter BVL, Brearley CA. Whitfield H, et al. Among authors: brearley ca. Plant Soil. 2018 Jun;427(1-2):149-161. doi: 10.1007/s11104-017-3315-9. Epub 2017 Jun 27. Plant Soil. 2018. PMID: 29880988 Free PMC article.

2

Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.

Baños-Sanz JI, Sanz-Aparicio J, Whitfield H, Hamilton C, Brearley CA, González B. Baños-Sanz JI, et al. Among authors: brearley ca. J Biol Chem. 2012 Aug 24;287(35):29237-49. doi: 10.1074/jbc.M112.363671. Epub 2012 Jun 28. J Biol Chem. 2012. PMID: 22745128 Free PMC article.

3

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase.

Whitfield H, Gilmartin M, Baker K, Riley AM, Godage HY, Potter BVL, Hemmings AM, Brearley CA. Whitfield H, et al. Among authors: brearley ca. J Med Chem. 2018 Oct 11;61(19):8838-8846. doi: 10.1021/acs.jmedchem.8b01022. Epub 2018 Sep 19. J Med Chem. 2018. PMID: 30160967

4

Effect of phytase on intestinal phytate breakdown, plasma inositol concentrations, and glucose transporter type 4 abundance in muscle membranes of weanling pigs1.

Lu H, Kühn I, Bedford MR, Whitfield H, Brearley C, Adeola O, Ajuwon KM. Lu H, et al. J Anim Sci. 2019 Sep 3;97(9):3907-3919. doi: 10.1093/jas/skz234. J Anim Sci. 2019. PMID: 31294448 Free PMC article.

5

Regioisomeric Family of Novel Fluorescent Substrates for SHIP2.

White G, Prior C, Mills SJ, Baker K, Whitfield H, Riley AM, Oganesyan VS, Potter BVL, Brearley CA. White G, et al. Among authors: brearley ca. ACS Med Chem Lett. 2019 Oct 18;11(3):309-315. doi: 10.1021/acsmedchemlett.9b00368. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184962 Free PMC article.

6

Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P₃ Receptor.

Shipton ML, Riley AM, Rossi AM, Brearley CA, Taylor CW, Potter BVL. Shipton ML, et al. Among authors: brearley ca. J Med Chem. 2020 May 28;63(10):5442-5457. doi: 10.1021/acs.jmedchem.0c00215. Epub 2020 May 6. J Med Chem. 2020. PMID: 32286062 Free PMC article.

7

An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels.

Whitfield H, White G, Sprigg C, Riley AM, Potter BVL, Hemmings AM, Brearley CA. Whitfield H, et al. Among authors: brearley ca. Biochem J. 2020 Jul 31;477(14):2621-2638. doi: 10.1042/BCJ20200423. Biochem J. 2020. PMID: 32706850 Free PMC article.

8

Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.

Whitfield H, Hemmings AM, Mills SJ, Baker K, White G, Rushworth S, Riley AM, Potter BVL, Brearley CA. Whitfield H, et al. Among authors: brearley ca. J Med Chem. 2021 Apr 8;64(7):3813-3826. doi: 10.1021/acs.jmedchem.0c01944. Epub 2021 Mar 16. J Med Chem. 2021. PMID: 33724834 Free PMC article.

9

Characterisation of a soil MINPP phytase with remarkable long-term stability and activity from Acinetobacter sp.

Rix GD, Sprigg C, Whitfield H, Hemmings AM, Todd JD, Brearley CA. Rix GD, et al. Among authors: brearley ca. PLoS One. 2022 Aug 31;17(8):e0272015. doi: 10.1371/journal.pone.0272015. eCollection 2022. PLoS One. 2022. PMID: 36044476 Free PMC article.

10

Phytase dose-dependent response of kidney inositol phosphate levels in poultry.

Sprigg C, Whitfield H, Burton E, Scholey D, Bedford MR, Brearley CA. Sprigg C, et al. Among authors: brearley ca. PLoS One. 2022 Oct 19;17(10):e0275742. doi: 10.1371/journal.pone.0275742. eCollection 2022. PLoS One. 2022. PMID: 36260560 Free PMC article.

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