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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Zhao Y, et al. Among authors: grassetti av. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Print 2018 Aug 31. Biosci Rep. 2018. PMID: 29472314 Free PMC article.
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE. Krajewska M, et al. Among authors: grassetti av. Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y. Nat Commun. 2019. PMID: 30988284 Free PMC article.