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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Zhao Y, et al. Among authors: cushing pr. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Print 2018 Aug 31. Biosci Rep. 2018. PMID: 29472314 Free PMC article.
Engineering peptide inhibitors to overcome PDZ binding promiscuity.
Vouilleme L, Cushing PR, Volkmer R, Madden DR, Boisguerin P. Vouilleme L, et al. Among authors: cushing pr. Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9912-6. doi: 10.1002/anie.201005575. Angew Chem Int Ed Engl. 2010. PMID: 21105032 Free PMC article. No abstract available.
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