Kohli RM - Search Results

1

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ. Fraietta JA, et al. Among authors: kohli rm. Nature. 2018 Jun;558(7709):307-312. doi: 10.1038/s41586-018-0178-z. Epub 2018 May 30. Nature. 2018. PMID: 29849141 Free PMC article.

2

TET enzymes, TDG and the dynamics of DNA demethylation.

Kohli RM, Zhang Y. Kohli RM, et al. Nature. 2013 Oct 24;502(7472):472-9. doi: 10.1038/nature12750. Nature. 2013. PMID: 24153300 Free PMC article. Review.

3

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.

Crawford DJ, Liu MY, Nabel CS, Cao XJ, Garcia BA, Kohli RM. Crawford DJ, et al. Among authors: kohli rm. J Am Chem Soc. 2016 Jan 27;138(3):730-3. doi: 10.1021/jacs.5b10554. Epub 2016 Jan 13. J Am Chem Soc. 2016. PMID: 26734843 Free PMC article.

4

The expanding scope and impact of epigenetic cytosine modifications.

Liu MY, DeNizio JE, Schutsky EK, Kohli RM. Liu MY, et al. Among authors: kohli rm. Curr Opin Chem Biol. 2016 Aug;33:67-73. doi: 10.1016/j.cbpa.2016.05.029. Epub 2016 Jun 14. Curr Opin Chem Biol. 2016. PMID: 27315338 Free PMC article. Review.

5

Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.

Liu MY, DeNizio JE, Kohli RM. Liu MY, et al. Among authors: kohli rm. Methods Enzymol. 2016;573:365-85. doi: 10.1016/bs.mie.2015.12.006. Epub 2016 Feb 1. Methods Enzymol. 2016. PMID: 27372762 Free PMC article.

6

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.

Liu MY, Torabifard H, Crawford DJ, DeNizio JE, Cao XJ, Garcia BA, Cisneros GA, Kohli RM. Liu MY, et al. Among authors: kohli rm. Nat Chem Biol. 2017 Feb;13(2):181-187. doi: 10.1038/nchembio.2250. Epub 2016 Dec 5. Nat Chem Biol. 2017. PMID: 27918559 Free PMC article.

7

DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia.

Nabel CS, DeNizio JE, Carroll M, Kohli RM. Nabel CS, et al. Among authors: kohli rm. Biochemistry. 2017 Apr 25;56(16):2166-2169. doi: 10.1021/acs.biochem.7b00208. Epub 2017 Apr 12. Biochemistry. 2017. PMID: 28394581 Free PMC article.

8

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.

Schutsky EK, Nabel CS, Davis AKF, DeNizio JE, Kohli RM. Schutsky EK, et al. Among authors: kohli rm. Nucleic Acids Res. 2017 Jul 27;45(13):7655-7665. doi: 10.1093/nar/gkx345. Nucleic Acids Res. 2017. PMID: 28472485 Free PMC article.

9

Harnessing natural DNA modifying activities for editing of the genome and epigenome.

DeNizio JE, Schutsky EK, Berrios KN, Liu MY, Kohli RM. DeNizio JE, et al. Among authors: kohli rm. Curr Opin Chem Biol. 2018 Aug;45:10-17. doi: 10.1016/j.cbpa.2018.01.016. Epub 2018 Feb 13. Curr Opin Chem Biol. 2018. PMID: 29452938 Free PMC article. Review.

10

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM. Schutsky EK, et al. Among authors: kohli rm. Nat Biotechnol. 2018 Oct 8:10.1038/nbt.4204. doi: 10.1038/nbt.4204. Online ahead of print. Nat Biotechnol. 2018. PMID: 30295673 Free PMC article.

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