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Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.
Luukkonen PK, Sädevirta S, Zhou Y, Kayser B, Ali A, Ahonen L, Lallukka S, Pelloux V, Gaggini M, Jian C, Hakkarainen A, Lundbom N, Gylling H, Salonen A, Orešič M, Hyötyläinen T, Orho-Melander M, Rissanen A, Gastaldelli A, Clément K, Hodson L, Yki-Järvinen H. Luukkonen PK, et al. Diabetes Care. 2018 Aug;41(8):1732-1739. doi: 10.2337/dc18-0071. Epub 2018 May 29. Diabetes Care. 2018. PMID: 29844096 Free PMC article. Clinical Trial.
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, Fisher RM, Ehrenborg E, Orho-Melander M, Ridderstråle M, Groop L, Yki-Järvinen H. Kotronen A, et al. Diabetologia. 2009 Jun;52(6):1056-60. doi: 10.1007/s00125-009-1285-z. Epub 2009 Feb 18. Diabetologia. 2009. PMID: 19224197 Free article.
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
Sevastianova K, Kotronen A, Gastaldelli A, Perttilä J, Hakkarainen A, Lundbom J, Suojanen L, Orho-Melander M, Lundbom N, Ferrannini E, Rissanen A, Olkkonen VM, Yki-Järvinen H. Sevastianova K, et al. Am J Clin Nutr. 2011 Jul;94(1):104-11. doi: 10.3945/ajcn.111.012369. Epub 2011 Apr 27. Am J Clin Nutr. 2011. PMID: 21525193 Free article. Clinical Trial.
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects.
Taskinen MR, Adiels M, Westerbacka J, Söderlund S, Kahri J, Lundbom N, Lundbom J, Hakkarainen A, Olofsson SO, Orho-Melander M, Borén J. Taskinen MR, et al. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2144-50. doi: 10.1161/ATVBAHA.111.224808. Epub 2011 Jul 21. Arterioscler Thromb Vasc Biol. 2011. PMID: 21778423
Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
Matikainen N, Burza MA, Romeo S, Hakkarainen A, Adiels M, Folkersen L, Eriksson P, Lundbom N, Ehrenborg E, Orho-Melander M, Taskinen MR, Borén J. Matikainen N, et al. PLoS One. 2013 Nov 20;8(11):e79473. doi: 10.1371/journal.pone.0079473. eCollection 2013. PLoS One. 2013. PMID: 24278138 Free PMC article. Clinical Trial.
341 results