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Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Saiki JP, et al. Among authors: von eyben r. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24. Proc Natl Acad Sci U S A. 2018. PMID: 29794221 Free PMC article.
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Aguilera TA, et al. Among authors: von eyben r. Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898. Nat Commun. 2016. PMID: 28008921 Free PMC article.
Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.
Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT. Nambiar DK, et al. Among authors: von eyben r. J Clin Invest. 2019 Dec 2;129(12):5553-5567. doi: 10.1172/JCI129025. J Clin Invest. 2019. PMID: 31710313 Free PMC article.
Validated limited gene predictor for cervical cancer lymph node metastases.
Bloomstein JD, von Eyben R, Chan A, Rankin EB, Fregoso DR, Wang-Chiang J, Lee L, Xie LX, David SM, Stehr H, Esfahani MS, Giaccia AJ, Kidd EA. Bloomstein JD, et al. Among authors: von eyben r. Oncotarget. 2020 Jun 16;11(24):2302-2309. doi: 10.18632/oncotarget.27632. eCollection 2020 Jun 16. Oncotarget. 2020. PMID: 32595829 Free PMC article.
The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB. Xiao Y, et al. Among authors: von eyben r. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817424 Free PMC article.
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. Among authors: von eyben r. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.
NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.
Guan L, Nambiar DK, Cao H, Viswanathan V, Kwok S, Hui AB, Hou Y, Hildebrand R, von Eyben R, Holmes BJ, Zhao J, Kong CS, Wamsley N, Zhang W, Major MB, Seol SW, Sunwoo JB, Hayes DN, Diehn M, Le QT. Guan L, et al. Among authors: von eyben r. Cancer Res. 2023 Mar 15;83(6):861-874. doi: 10.1158/0008-5472.CAN-22-1903. Cancer Res. 2023. PMID: 36652552 Free PMC article.
156 results