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Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Saiki JP, et al. Among authors: cao h. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24. Proc Natl Acad Sci U S A. 2018. PMID: 29794221 Free PMC article.
Neurotrophic factor GDNF promotes survival of salivary stem cells.
Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Xiao N, et al. Among authors: cao h. J Clin Invest. 2014 Aug;124(8):3364-77. doi: 10.1172/JCI74096. Epub 2014 Jul 18. J Clin Invest. 2014. PMID: 25036711 Free PMC article.
Botulinum Toxin Confers Radioprotection in Murine Salivary Glands.
Zeidan YH, Xiao N, Cao H, Kong C, Le QT, Sirjani D. Zeidan YH, et al. Among authors: cao h. Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1190-7. doi: 10.1016/j.ijrobp.2015.12.371. Epub 2015 Dec 29. Int J Radiat Oncol Biol Phys. 2016. PMID: 26907915 Free PMC article.
Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.
Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT. Nambiar DK, et al. Among authors: cao h. J Clin Invest. 2019 Dec 2;129(12):5553-5567. doi: 10.1172/JCI129025. J Clin Invest. 2019. PMID: 31710313 Free PMC article.
The role of Glial cell derived neurotrophic factor in head and neck cancer.
Cao H, He Q, Eyben RV, Bloomstein J, Nambiar DK, Viswanathan V, Aggarwal S, Kwok S, Liang R, Koong AJ, Lewis JS Jr, Kong C, Xiao N, Le QT. Cao H, et al. PLoS One. 2020 Feb 21;15(2):e0229311. doi: 10.1371/journal.pone.0229311. eCollection 2020. PLoS One. 2020. PMID: 32084217 Free PMC article.
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. Among authors: cao h. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.
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