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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD. Stöppler D, et al. Among authors: macpherson a. PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. eCollection 2018 May. PLoS Biol. 2018. PMID: 29782488 Free PMC article.
The Chemical Synthesis of Knob Domain Antibody Fragments.
Macpherson A, Birtley JR, Broadbridge RJ, Brady K, Schulze MED, Tang Y, Joyce C, Saunders K, Bogle G, Horton J, Kelm S, Taylor RD, Franklin RJ, Selby MD, Laabei M, Wonfor T, Hold A, Stanley P, Vadysirisack D, Shi J, van den Elsen J, Lawson ADG. Macpherson A, et al. ACS Chem Biol. 2021 Sep 17;16(9):1757-1769. doi: 10.1021/acschembio.1c00472. Epub 2021 Aug 18. ACS Chem Biol. 2021. PMID: 34406751 Free article.
Phage Display of Bovine Ultralong CDRH3.
Joyce C, Speight L, Lawson ADG, Scott-Tucker A, Macpherson A. Joyce C, et al. Among authors: macpherson a. Methods Mol Biol. 2023;2681:83-97. doi: 10.1007/978-1-0716-3279-6_6. Methods Mol Biol. 2023. PMID: 37405644
Modular design of bi- and multi-specific knob domain fusions.
Kuravsky M, Gibbons GF, Joyce C, Scott-Tucker A, Macpherson A, Lawson ADG. Kuravsky M, et al. Among authors: macpherson a. Front Immunol. 2024 Mar 27;15:1384467. doi: 10.3389/fimmu.2024.1384467. eCollection 2024. Front Immunol. 2024. PMID: 38605965 Free PMC article.
The allosteric modulation of complement C5 by knob domain peptides.
Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM. Macpherson A, et al. Elife. 2021 Feb 11;10:e63586. doi: 10.7554/eLife.63586. Elife. 2021. PMID: 33570492 Free PMC article.
Taking a hybrid biophysical approach, we present C5-knob domain co-crystal structures and, by solution methods, observed allosteric effects propagating >50 A from the binding sites. ...But it was unclear whether the knob domains from cows' antibodies could also h …
Taking a hybrid biophysical approach, we present C5-knob domain co-crystal structures and, by solution methods, observed allosteric e …
Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Wahid AA, et al. Among authors: macpherson a. Front Immunol. 2021 Aug 9;12:714055. doi: 10.3389/fimmu.2021.714055. eCollection 2021. Front Immunol. 2021. PMID: 34434196 Free PMC article.
742 results