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Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn.
Park YH, Kim DK, Kim HW, Kim HS, Lee D, Lee MB, Min KY, Koo J, Kim SJ, Kang C, Kim YM, Kim HS, Choi WS. Park YH, et al. Among authors: kim hw, kim ym, kim dk, kim sj, kim hs. Biochem Pharmacol. 2018 Aug;154:270-277. doi: 10.1016/j.bcp.2018.05.012. Epub 2018 May 17. Biochem Pharmacol. 2018. PMID: 29777684
An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppresses activation of Fyn kinase in mast cells and IgE-mediated allergic responses in mice.
Lee JH, Kim TH, Kim HS, Kim AR, Kim DK, Nam ST, Kim HW, Park YH, Her E, Park YM, Kim HS, Kim YM, Choi WS. Lee JH, et al. Among authors: kim hw, kim ar, kim th, kim ym, kim dk, kim hs. Toxicol Appl Pharmacol. 2015 Jun 15;285(3):179-86. doi: 10.1016/j.taap.2015.04.009. Epub 2015 Apr 19. Toxicol Appl Pharmacol. 2015. PMID: 25902337
Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production.
Tobío A, Bandara G, Morris DA, Kim DK, O'Connell MP, Komarow HD, Carter MC, Smrz D, Metcalfe DD, Olivera A. Tobío A, et al. Among authors: kim dk. Haematologica. 2020 Jan;105(1):124-135. doi: 10.3324/haematol.2018.212126. Epub 2019 Apr 4. Haematologica. 2020. PMID: 30948489 Free PMC article.
Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis.
Muñoz-Cano R, Pascal M, Bartra J, Picado C, Valero A, Kim DK, Brooks S, Ombrello M, Metcalfe DD, Rivera J, Olivera A. Muñoz-Cano R, et al. Among authors: kim dk. J Allergy Clin Immunol. 2016 Jan;137(1):137-146. doi: 10.1016/j.jaci.2015.05.042. Epub 2015 Jul 17. J Allergy Clin Immunol. 2016. PMID: 26194548 Free PMC article.
3,986 results