Shelton DL - Search Results

1

Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments.

Gropp KE, Carlson CS, Evans MG, Bagi CM, Reagan WJ, Hurst SI, Shelton DL, Zorbas MA. Gropp KE, et al. Among authors: shelton dl. Toxicol Pathol. 2018 Jun;46(4):408-420. doi: 10.1177/0192623318772501. Epub 2018 May 16. Toxicol Pathol. 2018. PMID: 29768985

2

Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.

LaBranche TP, Bendele AM, Omura BC, Gropp KE, Hurst SI, Bagi CM, Cummings TR, Grantham LE 2nd, Shelton DL, Zorbas MA. LaBranche TP, et al. Among authors: shelton dl. Ann Rheum Dis. 2017 Jan;76(1):295-302. doi: 10.1136/annrheumdis-2015-208913. Epub 2016 Jul 5. Ann Rheum Dis. 2017. PMID: 27381034 Free PMC article.

3

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor.

Butt M, Evans M, Bowman CJ, Cummings T, Oneda S, Shelton D, Zorbas M. Butt M, et al. Toxicol Sci. 2014 Dec;142(2):463-76. doi: 10.1093/toxsci/kfu192. Epub 2014 Oct 17. Toxicol Sci. 2014. PMID: 25326242

4

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

Bowman CJ, Evans M, Cummings T, Oneda S, Butt M, Hurst S, Gremminger JL, Shelton D, Kamperschroer C, Zorbas M. Bowman CJ, et al. Reprod Toxicol. 2015 Jun;53:105-18. doi: 10.1016/j.reprotox.2014.10.004. Epub 2014 Oct 14. Reprod Toxicol. 2015. PMID: 25461901

5

From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment.

Belanger P, Butler P, Butt M, Bhatt S, Foote S, Shelton D, Evans M, Arends R, Hurst S, Okerberg C, Cummings T, Potter D, Steidl-Nichols J, Zorbas M. Belanger P, et al. Toxicol Sci. 2017 Aug 1;158(2):319-333. doi: 10.1093/toxsci/kfx089. Toxicol Sci. 2017. PMID: 28525647 Free PMC article.

6

A multiple-dose toxicity study of tanezumab in cynomolgus monkeys.

Zorbas M, Hurst S, Shelton D, Evans M, Finco D, Butt M. Zorbas M, et al. Regul Toxicol Pharmacol. 2011 Mar;59(2):334-42. doi: 10.1016/j.yrtph.2010.11.005. Epub 2010 Dec 3. Regul Toxicol Pharmacol. 2011. PMID: 21130822

7

Sciatic nerve regeneration is not inhibited by anti-NGF antibody treatment in the adult rat.

Lankford KL, Arroyo EJ, Liu CN, Somps CJ, Zorbas MA, Shelton DL, Evans MG, Hurst SI, Kocsis JD. Lankford KL, et al. Among authors: shelton dl. Neuroscience. 2013 Jun 25;241:157-69. doi: 10.1016/j.neuroscience.2013.03.024. Epub 2013 Mar 24. Neuroscience. 2013. PMID: 23531437

8

Development of nerve growth factor (NGF) inhibition as a strategy for treatment of pain.

Shelton D. Shelton D. J Peripher Nerv Syst. 2014 Oct;19 Suppl 2:S12-3. doi: 10.1111/jns.12080_3. J Peripher Nerv Syst. 2014. PMID: 25269729 Review. No abstract available.

9

A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.

Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE, Ghilardi JR, Rosol TJ, Boustany L, Shelton DL, Mantyh PW. Halvorson KG, et al. Among authors: shelton dl. Cancer Res. 2005 Oct 15;65(20):9426-35. doi: 10.1158/0008-5472.CAN-05-0826. Cancer Res. 2005. PMID: 16230406

10

Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.

Chaparro-Riggers J, Liang H, DeVay RM, Bai L, Sutton JE, Chen W, Geng T, Lindquist K, Casas MG, Boustany LM, Brown CL, Chabot J, Gomes B, Garzone P, Rossi A, Strop P, Shelton D, Pons J, Rajpal A. Chaparro-Riggers J, et al. J Biol Chem. 2012 Mar 30;287(14):11090-7. doi: 10.1074/jbc.M111.319764. Epub 2012 Jan 31. J Biol Chem. 2012. PMID: 22294692 Free PMC article.

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