Saavedra OM - Search Results

1

Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.

Kanazawa H, Saavedra OM, Maianti JP, Young SA, Izquierdo L, Smith TK, Hanessian S, Kondo J. Kanazawa H, et al. Among authors: saavedra om. ChemMedChem. 2018 Aug 10;13(15):1541-1548. doi: 10.1002/cmdc.201800166. Epub 2018 Jul 4. ChemMedChem. 2018. PMID: 29766661

2

Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue.

Hanessian S, Giguère A, Grzyb J, Maianti JP, Saavedra OM, Aggen JB, Linsell MS, Goldblum AA, Hildebrandt DJ, Kane TR, Dozzo P, Gliedt MJ, Matias RD, Feeney LA, Armstrong ES. Hanessian S, et al. Among authors: saavedra om. ACS Med Chem Lett. 2011 Sep 29;2(12):924-8. doi: 10.1021/ml200202y. eCollection 2011 Dec 8. ACS Med Chem Lett. 2011. PMID: 24900282 Free PMC article.

3

Design and synthesis of bridged piperidine and piperazine isosteres.

Maertens G, Saavedra OM, Vece V, Reyes MAV, Hocine S, Öney E, Goument B, Mirguet O, Le Tiran A, Gloanec P, Hanessian S. Maertens G, et al. Among authors: saavedra om. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2627-2630. doi: 10.1016/j.bmcl.2018.06.038. Epub 2018 Jun 19. Bioorg Med Chem Lett. 2018. PMID: 29937060

4

Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells.

Hanessian S, Zhan L, Bovey R, Saavedra OM, Juillerat-Jeanneret L. Hanessian S, et al. Among authors: saavedra om. J Med Chem. 2003 Aug 14;46(17):3600-11. doi: 10.1021/jm0205853. J Med Chem. 2003. PMID: 12904064

5

Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines.

Hanessian S, Saavedra OM, Xie F, Amboldi N, Battistini C. Hanessian S, et al. Among authors: saavedra om. Bioorg Med Chem Lett. 2000 Mar 6;10(5):439-42. doi: 10.1016/s0960-894x(00)00022-6. Bioorg Med Chem Lett. 2000. PMID: 10743943

6

Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT₆ receptor ligands with significant selectivity for D₃ over D₂ receptors.

Saavedra OM, Karila D, Brossard D, Rojas A, Dupuis D, Gohier A, Mannoury la Cour C, Millan MJ, Ortuno JC, Hanessian S. Saavedra OM, et al. Bioorg Med Chem. 2017 Jan 1;25(1):38-52. doi: 10.1016/j.bmc.2016.10.010. Epub 2016 Oct 12. Bioorg Med Chem. 2017. PMID: 28029458

7

alpha- and beta-homogalactonojirimycins (alpha- and beta-homogalactostatins): synthesis and further biological evaluation.

Martin OR, Saavedra OM, Xie F, Liu L, Picasso S, Vogel P, Kizu H, Asano N. Martin OR, et al. Among authors: saavedra om. Bioorg Med Chem. 2001 May;9(5):1269-78. doi: 10.1016/s0968-0896(00)00343-6. Bioorg Med Chem. 2001. PMID: 11377185

8

Identification of a novel series of potent RON receptor tyrosine kinase inhibitors.

Raeppel S, Gaudette F, Mannion M, Claridge S, Saavedra O, Isakovic L, Déziel R, Beaulieu N, Beaulieu C, Dupont I, Nguyen H, Wang J, Macleod AR, Maroun C, Besterman JM, Vaisburg A. Raeppel S, et al. Bioorg Med Chem Lett. 2010 May 1;20(9):2745-9. doi: 10.1016/j.bmcl.2010.03.073. Epub 2010 Mar 19. Bioorg Med Chem Lett. 2010. PMID: 20363625

9

N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Mannion M, Raeppel S, Claridge S, Zhou N, Saavedra O, Isakovic L, Zhan L, Gaudette F, Raeppel F, Déziel R, Beaulieu N, Nguyen H, Chute I, Beaulieu C, Dupont I, Robert MF, Lefebvre S, Dubay M, Rahil J, Wang J, Ste-Croix H, Robert Macleod A, Besterman JM, Vaisburg A. Mannion M, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6552-6. doi: 10.1016/j.bmcl.2009.10.040. Epub 2009 Oct 13. Bioorg Med Chem Lett. 2009. PMID: 19854051

10

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.

Paquin I, Raeppel S, Leit S, Gaudette F, Zhou N, Moradei O, Saavedra O, Bernstein N, Raeppel F, Bouchain G, Fréchette S, Woo SH, Vaisburg A, Fournel M, Kalita A, Robert MF, Lu A, Trachy-Bourget MC, Yan PT, Liu J, Rahil J, MacLeod AR, Besterman JM, Li Z, Delorme D. Paquin I, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1067-71. doi: 10.1016/j.bmcl.2007.12.009. Epub 2007 Dec 10. Bioorg Med Chem Lett. 2008. PMID: 18160287

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