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Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists.
Bolchi C, Valoti E, Gotti C, Fasoli F, Ruggeri P, Fumagalli L, Binda M, Mucchietto V, Sciaccaluga M, Budriesi R, Fucile S, Pallavicini M. Bolchi C, et al. Among authors: sciaccaluga m. J Med Chem. 2015 Aug 27;58(16):6665-77. doi: 10.1021/acs.jmedchem.5b00904. Epub 2015 Aug 18. J Med Chem. 2015. PMID: 26225816 Free article.
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype.
Matera C, Quadri M, Sciaccaluga M, Pomè DY, Fasoli F, De Amici M, Fucile S, Gotti C, Dallanoce C, Grazioso G. Matera C, et al. Among authors: sciaccaluga m. Eur J Med Chem. 2016 Jan 27;108:392-405. doi: 10.1016/j.ejmech.2015.11.045. Epub 2015 Dec 5. Eur J Med Chem. 2016. PMID: 26706350 Free article.
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor.
Bolchi C, Bavo F, Gotti C, Fumagalli L, Fasoli F, Binda M, Mucchietto V, Sciaccaluga M, Plutino S, Fucile S, Pallavicini M. Bolchi C, et al. Among authors: sciaccaluga m. Eur J Med Chem. 2017 Jan 5;125:1132-1144. doi: 10.1016/j.ejmech.2016.10.048. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27810599
The fifth subunit in α3β4 nicotinic receptor is more than an accessory subunit.
Crespi A, Plutino S, Sciaccaluga M, Righi M, Borgese N, Fucile S, Gotti C, Colombo SF. Crespi A, et al. Among authors: sciaccaluga m. FASEB J. 2018 Aug;32(8):4190-4202. doi: 10.1096/fj.201701377R. Epub 2018 Mar 5. FASEB J. 2018. PMID: 29505300
Moreover, the LFM export motif of beta4 subunit in the fifth position exerts a unique function in the regulation of the intracellular trafficking of the receptors, their exposure at the cell surface, and consequently, their function, whereas the same export motif present in the b …
Moreover, the LFM export motif of beta4 subunit in the fifth position exerts a unique function in the regulation of the intracellular traffi …
Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism.
Martinelli S, Cordeddu V, Galosi S, Lanzo A, Palma E, Pannone L, Ciolfi A, Di Nottia M, Rizza T, Bocchinfuso G, Traversa A, Caputo V, Farrotti A, Carducci C, Bernardini L, Cogo S, Paglione M, Venditti M, Bentivoglio A, Ng J, Kurian MA, Civiero L, Greggio E, Stella L, Trettel F, Sciaccaluga M, Roseti C, Carrozzo R, Fucile S, Limatola C, Di Schiavi E, Tartaglia M, Leuzzi V. Martinelli S, et al. Among authors: sciaccaluga m. Parkinsonism Relat Disord. 2020 Mar;72:75-79. doi: 10.1016/j.parkreldis.2020.02.003. Epub 2020 Feb 15. Parkinsonism Relat Disord. 2020. PMID: 32120303
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