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From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor.
Bolchi C, Bavo F, Gotti C, Fumagalli L, Fasoli F, Binda M, Mucchietto V, Sciaccaluga M, Plutino S, Fucile S, Pallavicini M. Bolchi C, et al. Among authors: plutino s. Eur J Med Chem. 2017 Jan 5;125:1132-1144. doi: 10.1016/j.ejmech.2016.10.048. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27810599
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.
Murineddu G, Gotti C, Asproni B, Corona P, Martinello K, Plutino S, Fucile S, Temml V, Moretti M, Viani P, Schuster D, Piras S, Deligia F, Pinna GA. Murineddu G, et al. Among authors: plutino s. Eur J Med Chem. 2019 Oct 15;180:51-61. doi: 10.1016/j.ejmech.2019.06.079. Epub 2019 Jul 5. Eur J Med Chem. 2019. PMID: 31299587 Free article.