Gardiner JM - Search Results

1

Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS. Currin A, et al. Among authors: gardiner jm. ACS Catal. 2018 Mar 2;8(3):2012-2020. doi: 10.1021/acscatal.7b04115. Epub 2018 Jan 24. ACS Catal. 2018. PMID: 29750129 Free PMC article.

2

Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum.

Mansell DJ, Toogood HS, Waller J, Hughes JM, Levy CW, Gardiner JM, Scrutton NS. Mansell DJ, et al. Among authors: gardiner jm. ACS Catal. 2013 Mar 1;3(3):370-379. doi: 10.1021/cs300709m. Epub 2013 Jan 21. ACS Catal. 2013. PMID: 27547488 Free PMC article.

3

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS. Karuppiah V, et al. Among authors: gardiner jm. ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9. ACS Catal. 2017. PMID: 28966840 Free PMC article.

4

Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.

Lygidakis A, Karuppiah V, Hoeven R, Ní Cheallaigh A, Leys D, Gardiner JM, Toogood HS, Scrutton NS. Lygidakis A, et al. Among authors: gardiner jm. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9596-600. doi: 10.1002/anie.201603785. Epub 2016 Jul 13. Angew Chem Int Ed Engl. 2016. PMID: 27411040 Free PMC article.

5

Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.

Lygidakis A, Karuppiah V, Hoeven R, Ní Cheallaigh A, Leys D, Gardiner JM, Toogood HS, Scrutton NS. Lygidakis A, et al. Among authors: gardiner jm. Angew Chem Weinheim Bergstr Ger. 2016 Aug 8;128(33):9748-9752. doi: 10.1002/ange.201603785. Epub 2016 Jul 13. Angew Chem Weinheim Bergstr Ger. 2016. PMID: 27587903 Free PMC article.

6

Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway.

Cheallaigh AN, Mansell DJ, Toogood HS, Tait S, Lygidakis A, Scrutton NS, Gardiner JM. Cheallaigh AN, et al. Among authors: gardiner jm. J Nat Prod. 2018 Jul 27;81(7):1546-1552. doi: 10.1021/acs.jnatprod.7b01026. Epub 2018 Jul 6. J Nat Prod. 2018. PMID: 29979593

7

C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones.

Issa IS, Toogood HS, Johannissen LO, Raftery J, Scrutton NS, Gardiner JM. Issa IS, et al. Among authors: gardiner jm. Chemistry. 2019 Feb 26;25(12):2983-2988. doi: 10.1002/chem.201805219. Epub 2019 Jan 15. Chemistry. 2019. PMID: 30468546 Free PMC article.

8

Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase.

Toogood HS, Fryszkowska A, Hare V, Fisher K, Roujeinikova A, Leys D, Gardiner JM, Stephens GM, Scrutton NS. Toogood HS, et al. Among authors: gardiner jm. Adv Synth Catal. 2008 Nov 17;350(17):2789-2803. doi: 10.1002/adsc.200800561. Adv Synth Catal. 2008. PMID: 20396603 Free PMC article.

9

Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation.

Fryszkowska A, Toogood H, Sakuma M, Gardiner JM, Stephens GM, Scrutton NS. Fryszkowska A, et al. Among authors: gardiner jm. Adv Synth Catal. 2009 Nov;351(17):2976-2990. doi: 10.1002/adsc.200900603. Adv Synth Catal. 2009. PMID: 20396613 Free PMC article.

10

Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli.

Toogood HS, Ní Cheallaigh A, Tait S, Mansell DJ, Jervis A, Lygidakis A, Humphreys L, Takano E, Gardiner JM, Scrutton NS. Toogood HS, et al. Among authors: gardiner jm. ACS Synth Biol. 2015 Oct 16;4(10):1112-23. doi: 10.1021/acssynbio.5b00092. Epub 2015 Jun 5. ACS Synth Biol. 2015. PMID: 26017480 Free article.

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