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Page 1
Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.
Simões-Silva MR, De Araújo JS, Oliveira GM, Demarque KC, Peres RB, D'Almeida-Melo I, Batista DGJ, Da Silva CF, Cardoso-Santos C, Da Silva PB, Batista MM, Bahia MT, Soeiro MNC. Simões-Silva MR, et al. Among authors: peres rb. Biochem Pharmacol. 2017 Dec 1;145:46-53. doi: 10.1016/j.bcp.2017.08.025. Epub 2017 Sep 7. Biochem Pharmacol. 2017. PMID: 28870526
In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.
Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC. Nefertiti ASG, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29203485 Free PMC article.
In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi.
Santos CC, Lionel JR, Peres RB, Batista MM, da Silva PB, de Oliveira GM, da Silva CF, Batista DGJ, Souza SMO, Andrade CH, Neves BJ, Braga RC, Patrick DA, Bakunova SM, Tidwell RR, Soeiro MNC. Santos CC, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e02205-17. doi: 10.1128/AAC.02205-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29203486 Free PMC article.
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
Ferreira de Almeida Fiuza L, Peres RB, Simões-Silva MR, da Silva PB, Batista DDGJ, da Silva CF, Nefertiti Silva da Gama A, Krishna Reddy TR, Soeiro MNC. Ferreira de Almeida Fiuza L, et al. Among authors: peres rb. Eur J Med Chem. 2018 Apr 10;149:257-268. doi: 10.1016/j.ejmech.2018.02.020. Epub 2018 Feb 23. Eur J Med Chem. 2018. PMID: 29501946 Free article.
Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity.
Araujo-Lima CF, Peres RB, Silva PB, Batista MM, Aiub CAF, Felzenszwalb I, Soeiro MNC. Araujo-Lima CF, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00979-18. doi: 10.1128/AAC.00979-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987140 Free PMC article.
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
De Araújo JS, da Silva PB, Batista MM, Peres RB, Cardoso-Santos C, Kalejaiye TD, Munday JC, De Heuvel E, Sterk GJ, Augustyns K, Salado IG, Matheeussen A, De Esch I, De Koning HP, Leurs R, Maes L, Soeiro MNC. De Araújo JS, et al. Among authors: peres rb. J Antimicrob Chemother. 2020 Apr 1;75(4):958-967. doi: 10.1093/jac/dkz516. J Antimicrob Chemother. 2020. PMID: 31860098
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Fonseca-Berzal C, da Silva CF, Batista DDGJ, de Oliveira GM, Cumella J, Batista MM, Peres RB, Silva da Gama Nefertiti A, Escario JA, Gómez-Barrio A, Arán VJ, Soeiro MNC. Fonseca-Berzal C, et al. Among authors: peres rb. Parasitology. 2020 Sep;147(11):1216-1228. doi: 10.1017/S0031182020000955. Epub 2020 Jun 12. Parasitology. 2020. PMID: 32530391 Free PMC article.
Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids.
de Araújo JS, Peres RB, Bernardino da Silva P, Batista MM, Sterk GJ, Maes L, Caljon G, Leurs R, de Koning HP, Kalejaiye TD, Soeiro MNC. de Araújo JS, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2021 Feb 17;65(3):e00960-20. doi: 10.1128/AAC.00960-20. Print 2021 Feb 17. Antimicrob Agents Chemother. 2021. PMID: 33361300 Free PMC article.
21 results