Chaugule VK - Search Results

1

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM. Bustos F, et al. Among authors: chaugule vk. Cell Rep. 2018 May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022. Cell Rep. 2018. PMID: 29742418 Free PMC article.

2

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H. Chaugule VK, et al. EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204. EMBO J. 2011. PMID: 21694720 Free PMC article.

3

Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

Burchell L, Chaugule VK, Walden H. Burchell L, et al. Among authors: chaugule vk. PLoS One. 2012;7(4):e34748. doi: 10.1371/journal.pone.0034748. Epub 2012 Apr 4. PLoS One. 2012. PMID: 22496854 Free PMC article.

4

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL.

Miles JA, Frost MG, Carroll E, Rowe ML, Howard MJ, Sidhu A, Chaugule VK, Alpi AF, Walden H. Miles JA, et al. Among authors: chaugule vk. J Biol Chem. 2015 Aug 21;290(34):20995-21006. doi: 10.1074/jbc.M115.675835. Epub 2015 Jul 6. J Biol Chem. 2015. PMID: 26149689 Free PMC article.

5

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. Kumar A, et al. Among authors: chaugule vk. EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7. EMBO J. 2015. PMID: 26254304 Free PMC article.

6

Specificity and disease in the ubiquitin system.

Chaugule VK, Walden H. Chaugule VK, et al. Biochem Soc Trans. 2016 Feb;44(1):212-27. doi: 10.1042/BST20150209. Biochem Soc Trans. 2016. PMID: 26862208 Free PMC article. Review.

7

Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3.

Alpi AF, Chaugule V, Walden H. Alpi AF, et al. Biochem J. 2016 Oct 15;473(20):3401-3419. doi: 10.1042/BCJ20160028. Biochem J. 2016. PMID: 27729585 Free PMC article. Review.

8

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H. Kumar A, et al. Among authors: chaugule vk. Nat Struct Mol Biol. 2017 May;24(5):475-483. doi: 10.1038/nsmb.3400. Epub 2017 Apr 17. Nat Struct Mol Biol. 2017. PMID: 28414322 Free PMC article.

9

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.

Morreale FE, Bortoluzzi A, Chaugule VK, Arkinson C, Walden H, Ciulli A. Morreale FE, et al. Among authors: chaugule vk. J Med Chem. 2017 May 11;60(9):4093-4098. doi: 10.1021/acs.jmedchem.7b00147. Epub 2017 May 2. J Med Chem. 2017. PMID: 28437106 Free PMC article.

10

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.

Morreale FE, Testa A, Chaugule VK, Bortoluzzi A, Ciulli A, Walden H. Morreale FE, et al. Among authors: chaugule vk. J Med Chem. 2017 Oct 12;60(19):8183-8191. doi: 10.1021/acs.jmedchem.7b01071. Epub 2017 Oct 3. J Med Chem. 2017. PMID: 28933844 Free PMC article.

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