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Clinical trials for BET inhibitors run ahead of the science.
Andrieu G, Belkina AC, Denis GV. Andrieu G, et al. Drug Discov Today Technol. 2016 Mar;19:45-50. doi: 10.1016/j.ddtec.2016.06.004. Epub 2016 Jul 21. Drug Discov Today Technol. 2016. PMID: 27769357 Free PMC article. Review.
PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL.
Andrieu GP, Kohn M, Simonin M, Smith CL, Cieslak A, Dourthe MÉ, Charbonnier G, Graux C, Huguet F, Lhéritier V, Dombret H, Spicuglia S, Rousselot P, Boissel N, Asnafi V. Andrieu GP, et al. Blood. 2021 Nov 11;138(19):1855-1869. doi: 10.1182/blood.2020010081. Blood. 2021. PMID: 34125178 Free PMC article. Clinical Trial.
104 results