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The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain.
Mirrasekhian E, Nilsson JLÅ, Shionoya K, Blomgren A, Zygmunt PM, Engblom D, Högestätt ED, Blomqvist A. Mirrasekhian E, et al. Among authors: blomgren a. FASEB J. 2018 Oct;32(10):5751-5759. doi: 10.1096/fj.201800272R. Epub 2018 May 8. FASEB J. 2018. PMID: 29738273 Free article.
Treatment of wild-type and TRPA1 knockout mice rendered febrile by immune challenge with LPS with a dose of paracetamol that did not produce hypothermia (150 mg/kg) but is known to be analgetic, abolished fever in both genotypes. ...We conclude that paracetamol's antipyret …
Treatment of wild-type and TRPA1 knockout mice rendered febrile by immune challenge with LPS with a dose of paracetamol that did not …
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1.
Zygmunt PM, Ermund A, Movahed P, Andersson DA, Simonsen C, Jönsson BA, Blomgren A, Birnir B, Bevan S, Eschalier A, Mallet C, Gomis A, Högestätt ED. Zygmunt PM, et al. Among authors: blomgren a. PLoS One. 2013 Dec 2;8(12):e81618. doi: 10.1371/journal.pone.0081618. eCollection 2013. PLoS One. 2013. PMID: 24312564 Free PMC article.
28 results