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Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mok SA, et al. Among authors: zweckstetter m. Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30. Nat Struct Mol Biol. 2018. PMID: 29728653 Free PMC article.
Imbalance of Hsp70 family variants fosters tau accumulation.
Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Jinwal UK, et al. Among authors: zweckstetter m. FASEB J. 2013 Apr;27(4):1450-9. doi: 10.1096/fj.12-220889. Epub 2012 Dec 27. FASEB J. 2013. PMID: 23271055 Free PMC article.
Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.
Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Karagöz GE, et al. Among authors: zweckstetter m. Cell. 2014 Feb 27;156(5):963-74. doi: 10.1016/j.cell.2014.01.037. Cell. 2014. PMID: 24581495 Free PMC article.
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, Mandelkow E, Zweckstetter M. Kadavath H, et al. Among authors: zweckstetter m. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6. doi: 10.1073/pnas.1504081112. Epub 2015 Jun 1. Proc Natl Acad Sci U S A. 2015. PMID: 26034266 Free PMC article.
Folding of the Tau Protein on Microtubules.
Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M. Kadavath H, et al. Among authors: zweckstetter m. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10347-51. doi: 10.1002/anie.201501714. Epub 2015 Jun 19. Angew Chem Int Ed Engl. 2015. PMID: 26094605
Structural Impact of Tau Phosphorylation at Threonine 231.
Schwalbe M, Kadavath H, Biernat J, Ozenne V, Blackledge M, Mandelkow E, Zweckstetter M. Schwalbe M, et al. Among authors: zweckstetter m. Structure. 2015 Aug 4;23(8):1448-1458. doi: 10.1016/j.str.2015.06.002. Epub 2015 Jul 9. Structure. 2015. PMID: 26165593 Free article.
292 results