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Page 1
Rational design of peptide derivatives for inhibition of MyD88-mediated toll-like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis.
Ryan DA, Degardin M, Alam S, Kissner TL, Hale M, Cameron MD, Rebek M, Ajami D, Saikh KU, Rebek J Jr. Ryan DA, et al. Among authors: rebek m. Chem Biol Drug Des. 2017 Dec;90(6):1190-1205. doi: 10.1111/cbdd.13039. Epub 2017 Jul 17. Chem Biol Drug Des. 2017. PMID: 28599094
A small molecule that mimics the BB-loop in the Toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice.
Kissner TL, Moisan L, Mann E, Alam S, Ruthel G, Ulrich RG, Rebek M, Rebek J Jr, Saikh KU. Kissner TL, et al. Among authors: rebek m. J Biol Chem. 2011 Sep 9;286(36):31385-96. doi: 10.1074/jbc.M110.204982. Epub 2011 Jun 21. J Biol Chem. 2011. PMID: 21693701 Free PMC article.
Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88.
Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU. Kissner TL, et al. Among authors: rebek m. PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27. PLoS One. 2012. PMID: 22848400 Free PMC article. Clinical Trial.