Lehner PJ - Search Results

1

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM. Robbez-Masson L, et al. Among authors: lehner pj. Genome Res. 2018 Jun;28(6):836-845. doi: 10.1101/gr.228171.117. Epub 2018 May 4. Genome Res. 2018. PMID: 29728366 Free PMC article.

2

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

Duncan LM, Timms RT, Zavodszky E, Cano F, Dougan G, Randow F, Lehner PJ. Duncan LM, et al. Among authors: lehner pj. PLoS One. 2012;7(6):e39651. doi: 10.1371/journal.pone.0039651. Epub 2012 Jun 22. PLoS One. 2012. PMID: 22745803 Free PMC article.

3

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ. Timms RT, et al. Among authors: lehner pj. PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278019 Free PMC article.

4

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ. van den Boomen DJ, et al. Among authors: lehner pj. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16. Proc Natl Acad Sci U S A. 2014. PMID: 25030448 Free PMC article.

5

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ. Tchasovnikarova IA, et al. Among authors: lehner pj. Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28. Science. 2015. PMID: 26022416 Free PMC article.

6

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ. Timms RT, et al. Among authors: lehner pj. Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Bioessays. 2016. PMID: 26853531 Review.

7

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ. Rapiteanu R, et al. Among authors: lehner pj. Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25. Traffic. 2016. PMID: 27126989 Free PMC article.

8

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ. Timms RT, et al. Among authors: lehner pj. Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786. Nat Commun. 2016. PMID: 27283361 Free PMC article.

9

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ. Timms RT, et al. Among authors: lehner pj. Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050. Cell Rep. 2016. PMID: 27732843 Free PMC article.

10

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA. Burr SP, et al. Among authors: lehner pj. Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27. Cell Metab. 2016. PMID: 27923773 Free PMC article.

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