Shadle SC - Search Results

1

Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscle.

Campbell AE, Belleville AE, Resnick R, Shadle SC, Tapscott SJ. Campbell AE, et al. Among authors: shadle sc. Hum Mol Genet. 2018 Aug 1;27(R2):R153-R162. doi: 10.1093/hmg/ddy162. Hum Mol Genet. 2018. PMID: 29718206 Free PMC article. Review.

2

Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.

Jagannathan S, Shadle SC, Resnick R, Snider L, Tawil RN, van der Maarel SM, Bradley RK, Tapscott SJ. Jagannathan S, et al. Among authors: shadle sc. Hum Mol Genet. 2016 Oct 15;25(20):4419-4431. doi: 10.1093/hmg/ddw271. Hum Mol Genet. 2016. PMID: 28171552 Free PMC article.

3

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.

Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. Shadle SC, et al. PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28273136 Free PMC article.

4

BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells.

Campbell AE, Oliva J, Yates MP, Zhong JW, Shadle SC, Snider L, Singh N, Tai S, Hiramuki Y, Tawil R, van der Maarel SM, Tapscott SJ, Sverdrup FM. Campbell AE, et al. Among authors: shadle sc. Skelet Muscle. 2017 Sep 4;7(1):16. doi: 10.1186/s13395-017-0134-x. Skelet Muscle. 2017. PMID: 28870238 Free PMC article.

5

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.

Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. Campbell AE, et al. Among authors: shadle sc. Elife. 2018 Mar 13;7:e31023. doi: 10.7554/eLife.31023. Elife. 2018. PMID: 29533181 Free PMC article.

6

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double-stranded RNA foci in human cell models of FSHD.

Shadle SC, Bennett SR, Wong CJ, Karreman NA, Campbell AE, van der Maarel SM, Bass BL, Tapscott SJ. Shadle SC, et al. Hum Mol Genet. 2019 Dec 1;28(23):3997-4011. doi: 10.1093/hmg/ddz242. Hum Mol Genet. 2019. PMID: 31630170 Free PMC article.

7

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade.

Chew GL, Campbell AE, De Neef E, Sutliff NA, Shadle SC, Tapscott SJ, Bradley RK. Chew GL, et al. Among authors: shadle sc. Dev Cell. 2019 Sep 9;50(5):658-671.e7. doi: 10.1016/j.devcel.2019.06.011. Epub 2019 Jul 18. Dev Cell. 2019. PMID: 31327741 Free PMC article.

8

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4.

Balog J, Thijssen PE, Shadle S, Straasheijm KR, van der Vliet PJ, Krom YD, van den Boogaard ML, de Jong A, F Lemmers RJ, Tawil R, Tapscott SJ, van der Maarel SM. Balog J, et al. Epigenetics. 2015;10(12):1133-42. doi: 10.1080/15592294.2015.1113798. Epigenetics. 2015. PMID: 26575099 Free PMC article.

9

p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.

Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR. Grow EJ, et al. Among authors: shadle sc. Nat Genet. 2021 Aug;53(8):1207-1220. doi: 10.1038/s41588-021-00893-0. Epub 2021 Jul 15. Nat Genet. 2021. PMID: 34267371 Free PMC article.

10

Corrigendum. Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4.

Balog J, Thijssen PE, Shadle S, Straasheijm KR, van der Vliet PJ, Krom YD, van den Boogaard ML, de Jong A, Lemmers RJ, Tawil R, Tapscott SJ, van der Maarel SM. Balog J, et al. Epigenetics. 2016;11(2):175. doi: 10.1080/15592294.2016.1161273. Epigenetics. 2016. PMID: 27058812 Free PMC article. No abstract available.

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