Deng L - Search Results

1

Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.

Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Christensen KE, et al. Among authors: deng l. J Nutr. 2018 Apr 1;148(4):501-509. doi: 10.1093/jn/nxy013. J Nutr. 2018. PMID: 29659962 Free article.

2

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.

Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R. Christensen KE, et al. Among authors: deng l. Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223. Epub 2013 May 23. Hum Mol Genet. 2013. PMID: 23704330

3

MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.

Jadavji NM, Deng L, Malysheva O, Caudill MA, Rozen R. Jadavji NM, et al. Among authors: deng l. Neuroscience. 2015 Aug 6;300:1-9. doi: 10.1016/j.neuroscience.2015.04.067. Epub 2015 May 6. Neuroscience. 2015. PMID: 25956258

4

Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.

Knock E, Deng L, Wu Q, Lawrance AK, Wang XL, Rozen R. Knock E, et al. Among authors: deng l. J Nutr. 2008 Apr;138(4):653-8. doi: 10.1093/jn/138.4.653. J Nutr. 2008. PMID: 18356316 Free article.

5

Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.

Chan J, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R. Chan J, et al. Among authors: deng l. Am J Clin Nutr. 2010 Apr;91(4):1035-43. doi: 10.3945/ajcn.2009.28754. Epub 2010 Feb 17. Am J Clin Nutr. 2010. PMID: 20164309 Free article.

6

Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.

Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R. Christensen KE, et al. Among authors: deng l. J Nutr. 2010 Oct;140(10):1736-41. doi: 10.3945/jn.110.124917. Epub 2010 Aug 19. J Nutr. 2010. PMID: 20724492 Free article.

7

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Leclerc D, Cao Y, Deng L, Mikael LG, Wu Q, Rozen R. Leclerc D, et al. Among authors: deng l. Mol Nutr Food Res. 2013 Apr;57(4):686-97. doi: 10.1002/mnfr.201200212. Epub 2012 Sep 24. Mol Nutr Food Res. 2013. PMID: 23001810

8

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Christensen KE, Mikael LG, Leung KY, Lévesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND, Rozen R. Christensen KE, et al. Among authors: deng l. Am J Clin Nutr. 2015 Mar;101(3):646-58. doi: 10.3945/ajcn.114.086603. Epub 2015 Jan 7. Am J Clin Nutr. 2015. PMID: 25733650 Free PMC article.

9

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.

Christensen KE, Deng L, Bahous RH, Jerome-Majewska LA, Rozen R. Christensen KE, et al. Among authors: deng l. Birth Defects Res A Clin Mol Teratol. 2015 Dec;103(12):1031-8. doi: 10.1002/bdra.23451. Epub 2015 Sep 26. Birth Defects Res A Clin Mol Teratol. 2015. PMID: 26408344

10

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.

Lévesque N, Christensen KE, Van Der Kraak L, Best AF, Deng L, Caldwell D, MacFarlane AJ, Beauchemin N, Rozen R. Lévesque N, et al. Among authors: deng l. Mol Carcinog. 2017 Mar;56(3):1030-1040. doi: 10.1002/mc.22568. Epub 2016 Nov 1. Mol Carcinog. 2017. PMID: 27597531

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