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Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
Peranzoni E, Lemoine J, Vimeux L, Feuillet V, Barrin S, Kantari-Mimoun C, Bercovici N, Guérin M, Biton J, Ouakrim H, Régnier F, Lupo A, Alifano M, Damotte D, Donnadieu E. Peranzoni E, et al. Among authors: guerin m. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4041-E4050. doi: 10.1073/pnas.1720948115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632196 Free PMC article.
TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors.
Guerin MV, Regnier F, Feuillet V, Vimeux L, Weiss JM, Bismuth G, Altan-Bonnet G, Guilbert T, Thoreau M, Finisguerra V, Donnadieu E, Trautmann A, Bercovici N. Guerin MV, et al. Nat Commun. 2019 Sep 11;10(1):4131. doi: 10.1038/s41467-019-11998-w. Nat Commun. 2019. PMID: 31511510 Free PMC article.
Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.
Boulch M, Cazaux M, Cuffel A, Guerin MV, Garcia Z, Alonso R, Lemaître F, Beer A, Corre B, Menger L, Grandjean CL, Morin F, Thieblemont C, Caillat-Zucman S, Bousso P. Boulch M, et al. Among authors: guerin mv. Nat Cancer. 2023 Jul;4(7):968-983. doi: 10.1038/s43018-023-00570-7. Epub 2023 May 29. Nat Cancer. 2023. PMID: 37248395 Free PMC article.
779 results