Burke JE - Search Results

1

Conformational sampling of membranes by Akt controls its activation and inactivation.

Lučić I, Rathinaswamy MK, Truebestein L, Hamelin DJ, Burke JE, Leonard TA. Lučić I, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3940-E3949. doi: 10.1073/pnas.1716109115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632185 Free PMC article.

2

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Burke JE, et al. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949682 Free PMC article.

3

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Vadas O, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24190998 Free PMC article.

4

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

Dornan GL, Siempelkamp BD, Jenkins ML, Vadas O, Lucas CL, Burke JE. Dornan GL, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1982-1987. doi: 10.1073/pnas.1617244114. Epub 2017 Feb 6. Proc Natl Acad Sci U S A. 2017. PMID: 28167755 Free PMC article.

5

Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas.

Siempelkamp BD, Rathinaswamy MK, Jenkins ML, Burke JE. Siempelkamp BD, et al. Among authors: burke je. J Biol Chem. 2017 Jul 21;292(29):12256-12266. doi: 10.1074/jbc.M117.789263. Epub 2017 May 17. J Biol Chem. 2017. PMID: 28515318 Free PMC article.

6

Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.

Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. Gentile DR, et al. Among authors: burke je. Cell Chem Biol. 2017 Dec 21;24(12):1455-1466.e14. doi: 10.1016/j.chembiol.2017.08.025. Epub 2017 Oct 12. Cell Chem Biol. 2017. PMID: 29033317 Free PMC article.

7

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex.

Dornan GL, Dalwadi U, Hamelin DJ, Hoffmann RM, Yip CK, Burke JE. Dornan GL, et al. Among authors: burke je. J Mol Biol. 2018 Sep 14;430(18 Pt B):3129-3142. doi: 10.1016/j.jmb.2018.07.020. Epub 2018 Jul 18. J Mol Biol. 2018. PMID: 30031006

8

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. Jenkins ML, et al. Among authors: burke je. Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z. Nat Commun. 2018. PMID: 30217979 Free PMC article.

9

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ. Powell CJ, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10548-E10555. doi: 10.1073/pnas.1811167115. Epub 2018 Oct 22. Proc Natl Acad Sci U S A. 2018. PMID: 30348763 Free PMC article.

10

Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.

Castro-Falcón G, Seiler GS, Demir Ö, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC. Castro-Falcón G, et al. Among authors: burke je. J Med Chem. 2018 Dec 13;61(23):10463-10472. doi: 10.1021/acs.jmedchem.8b00975. Epub 2018 Nov 28. J Med Chem. 2018. PMID: 30380865 Free PMC article.

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