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Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.
Hong CR, Mehta SY, Liyanage HDS, McManaway SP, Lee HH, Jaiswal JK, Bogle G, Tercel M, Pruijn FB, Wilson WR, Hicks KO. Hong CR, et al. Among authors: liyanage hds. Cancer Chemother Pharmacol. 2021 Oct;88(4):673-687. doi: 10.1007/s00280-021-04320-3. Epub 2021 Jul 10. Cancer Chemother Pharmacol. 2021. PMID: 34245333
Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Gu Y, Chang TT, Wang J, Jaiswal JK, Edwards D, Downes NJ, Liyanage HDS, Lynch CRH, Pruijn FB, Hickey AJR, Hay MP, Wilson WR, Hicks KO. Gu Y, et al. Among authors: liyanage hds. Front Pharmacol. 2017 Aug 11;8:531. doi: 10.3389/fphar.2017.00531. eCollection 2017. Front Pharmacol. 2017. PMID: 28848445 Free PMC article.
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
Hicks KO, Siim BG, Jaiswal JK, Pruijn FB, Fraser AM, Patel R, Hogg A, Liyanage HD, Dorie MJ, Brown JM, Denny WA, Hay MP, Wilson WR. Hicks KO, et al. Clin Cancer Res. 2010 Oct 15;16(20):4946-57. doi: 10.1158/1078-0432.CCR-10-1439. Epub 2010 Aug 20. Clin Cancer Res. 2010. PMID: 20732963 Free PMC article.
15 results