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Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy.
Eur J Pharmacol. 2018 Jun 15;829:44-53. doi: 10.1016/j.ejphar.2018.04.004. Epub 2018 Apr 5.
Eur J Pharmacol. 2018.
PMID: 29627311
Quantification of Intracellular Accumulation and Retention of Lysosomotropic Macrocyclic Compounds by High-Throughput Imaging of Lysosomal Changes.
Easwaranathan A, Inci B, Ulrich S, Brunken L, Nikiforova V, Norinder U, Swanson S, Munic Kos V.
Easwaranathan A, et al.
J Pharm Sci. 2019 Jan;108(1):652-660. doi: 10.1016/j.xphs.2018.11.001. Epub 2018 Nov 9.
J Pharm Sci. 2019.
PMID: 30419273
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