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Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: unno m. Cell Cycle. 2018;17(7):868-873. doi: 10.1080/15384101.2018.1445907. Epub 2018 May 21. Cell Cycle. 2018. PMID: 29623758 Free PMC article.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, Mano N, Nakano T, Lee Y, Shimizu S, Oba S, Fujiwara S, Shimizu H, Chen N, Nezhad ZK, Jin G, Fukushige S, Sunamura M, Ishida M, Motoi F, Egawa S, Unno M, Horii A. Saiki Y, et al. Among authors: unno m. Biochem Biophys Res Commun. 2012 Apr 27;421(1):98-104. doi: 10.1016/j.bbrc.2012.03.122. Epub 2012 Apr 3. Biochem Biophys Res Commun. 2012. PMID: 22490663
[Efficacy of neoadjuvant chemotherapy for resectable pancreatic carcinoma].
Motoi F, Kawaguchi K, Aoki T, Kudo K, Yabuuchi S, Fukase K, Mizuma M, Sakata N, Otsutomo S, Morikawa T, Hayashi H, Nakagawa K, Okada T, Yoshida H, Naitoh T, Katayose Y, Egawa S, Unno M. Motoi F, et al. Among authors: unno m. Gan To Kagaku Ryoho. 2013 Nov;40(12):1632-6. Gan To Kagaku Ryoho. 2013. PMID: 24393872 Japanese.
Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.
Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M. Komura T, et al. Among authors: unno m. Int J Clin Oncol. 2015 Feb;20(1):117-25. doi: 10.1007/s10147-014-0699-x. Epub 2014 May 8. Int J Clin Oncol. 2015. PMID: 24802097
964 results