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Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox.
Frey TR, Forsyth KS, Sheehan MM, De Haven BC, Pevarnik JG, Hand ES, Pizzorno MC, Eisenlohr LC, Hersperger AR. Frey TR, et al. Among authors: pevarnik jg. Virology. 2018 May;518:335-348. doi: 10.1016/j.virol.2018.03.016. Epub 2018 Mar 27. Virology. 2018. PMID: 29602068 Free PMC article.