Offen WA - Search Results

1

Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.

Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Schröder SP, et al. Among authors: offen wa. J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4. J Am Chem Soc. 2018. PMID: 29601200 Free PMC article.

2

Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9A resolution.

Vincent F, Charnock SJ, Verschueren KH, Turkenburg JP, Scott DJ, Offen WA, Roberts S, Pell G, Gilbert HJ, Davies GJ, Brannigan JA. Vincent F, et al. Among authors: offen wa. J Mol Biol. 2003 Jul 11;330(3):593-606. doi: 10.1016/s0022-2836(03)00632-6. J Mol Biol. 2003. PMID: 12842474

3

Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification.

Offen W, Martinez-Fleites C, Yang M, Kiat-Lim E, Davis BG, Tarling CA, Ford CM, Bowles DJ, Davies GJ. Offen W, et al. EMBO J. 2006 Mar 22;25(6):1396-405. doi: 10.1038/sj.emboj.7600970. Epub 2006 Feb 16. EMBO J. 2006. PMID: 16482224 Free PMC article.

4

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants.

Brazier-Hicks M, Offen WA, Gershater MC, Revett TJ, Lim EK, Bowles DJ, Davies GJ, Edwards R. Brazier-Hicks M, et al. Among authors: offen wa. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20238-43. doi: 10.1073/pnas.0706421104. Epub 2007 Dec 12. Proc Natl Acad Sci U S A. 2007. PMID: 18077347 Free PMC article.

5

Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.

Tailford LE, Offen WA, Smith NL, Dumon C, Morland C, Gratien J, Heck MP, Stick RV, Blériot Y, Vasella A, Gilbert HJ, Davies GJ. Tailford LE, et al. Among authors: offen wa. Nat Chem Biol. 2008 May;4(5):306-12. doi: 10.1038/nchembio.81. Nat Chem Biol. 2008. PMID: 18408714

6

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.

Offen WA, Zechel DL, Withers SG, Gilbert HJ, Davies GJ. Offen WA, et al. Chem Commun (Camb). 2009 May 14;(18):2484-6. doi: 10.1039/b902240f. Epub 2009 Apr 6. Chem Commun (Camb). 2009. PMID: 19532864

7

Structure and activity of Paenibacillus polymyxa xyloglucanase from glycoside hydrolase family 44.

Ariza A, Eklöf JM, Spadiut O, Offen WA, Roberts SM, Besenmatter W, Friis EP, Skjøt M, Wilson KS, Brumer H, Davies G. Ariza A, et al. Among authors: offen wa. J Biol Chem. 2011 Sep 30;286(39):33890-900. doi: 10.1074/jbc.M111.262345. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795708 Free PMC article.

8

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway.

Kim RQ, Offen WA, Davies GJ, Stubbs KA. Kim RQ, et al. Among authors: offen wa. Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):177-85. doi: 10.1107/S1399004713026655. Epub 2013 Dec 31. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24419390

9

Structure and activity of the Streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition.

Thi NN, Offen WA, Shareck F, Davies GJ, Doucet N. Thi NN, et al. Among authors: offen wa. Biochemistry. 2014 Mar 25;53(11):1789-800. doi: 10.1021/bi401697j. Epub 2014 Mar 11. Biochemistry. 2014. PMID: 24559145

10

Three-dimensional structure of a variant `Termamyl-like' Geobacillus stearothermophilus α-amylase at 1.9 Å resolution.

Offen WA, Viksoe-Nielsen A, Borchert TV, Wilson KS, Davies GJ. Offen WA, et al. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):66-70. doi: 10.1107/S2053230X14026508. Epub 2015 Jan 1. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 25615972 Free PMC article.

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