PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.
Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, Takimoto A, Yoshioka T, Lian C, Chen C, Zhang D, Zhang Y, Li S, Sun X, Tan Y, Yagi S, Frenkel EP, Hoffman RM.
Yang Z, et al.
Cancer Res. 2004 Sep 15;64(18):6673-8. doi: 10.1158/0008-5472.CAN-04-1822.
Cancer Res. 2004.
PMID: 15374983