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The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D. Fuchslocher Chico J, et al. Among authors: ruder b. Oncotarget. 2018 Feb 5;9(16):12941-12958. doi: 10.18632/oncotarget.24410. eCollection 2018 Feb 27. Oncotarget. 2018. PMID: 29560122 Free PMC article.
Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn's Disease.
Günther C, Ruder B, Stolzer I, Dorner H, He GW, Chiriac MT, Aden K, Strigli A, Bittel M, Zeissig S, Rosenstiel P, Atreya R, Neurath MF, Wirtz S, Becker C. Günther C, et al. Among authors: ruder b. Gastroenterology. 2019 Nov;157(5):1310-1322.e13. doi: 10.1053/j.gastro.2019.07.031. Epub 2019 Jul 25. Gastroenterology. 2019. PMID: 31352002
Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo.
Ruder B, Günther C, Stürzl M, Neurath MF, Cesarman E, Ballon G, Becker C. Ruder B, et al. PLoS One. 2020 Jan 30;15(1):e0228441. doi: 10.1371/journal.pone.0228441. eCollection 2020. PLoS One. 2020. PMID: 31999759 Free PMC article.
Investigating Intestinal Barrier Breakdown in Living Organoids.
Bardenbacher M, Ruder B, Britzen-Laurent N, Naschberger E, Becker C, Palmisano R, Stürzl M, Tripal P. Bardenbacher M, et al. Among authors: ruder b. J Vis Exp. 2020 Mar 26;(157). doi: 10.3791/60546. J Vis Exp. 2020. PMID: 32281970
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE. Mayr L, et al. Among authors: ruder b. Nat Commun. 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. Nat Commun. 2020. PMID: 32286299 Free PMC article.
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Patankar JV, Müller TM, Kantham S, Acera MG, Mascia F, Scheibe K, Mahapatro M, Heichler C, Yu Y, Li W, Ruder B, Günther C, Leppkes M, Mathew MJ, Wirtz S, Neufert C, Kühl AA, Paquette J, Jacobson K, Atreya R, Zundler S, Neurath MF, Young RN, Becker C. Patankar JV, et al. Among authors: ruder b. Nat Cell Biol. 2021 Jul;23(7):796-807. doi: 10.1038/s41556-021-00708-8. Epub 2021 Jul 8. Nat Cell Biol. 2021. PMID: 34239062
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