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Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.
Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, Huo X, Cheng E, Pham TH, Asanuma K, Hatanpaa KJ, Rezai D, Wang DH, Sarode V, Melton S, Genta RM, Spechler SJ, Souza RF. Zhang Q, et al. Among authors: zhang x. Gastroenterology. 2014 Feb;146(2):461-72.e6. doi: 10.1053/j.gastro.2013.10.011. Epub 2013 Oct 9. Gastroenterology. 2014. PMID: 24120473 Free PMC article.
In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids.
Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ. Peng S, et al. Among authors: zhang q, zhang x. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G129-39. doi: 10.1152/ajpgi.00085.2014. Epub 2014 May 22. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24852569 Free PMC article. Clinical Trial.
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