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Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
Ohoka N, Morita Y, Nagai K, Shimokawa K, Ujikawa O, Fujimori I, Ito M, Hayase Y, Okuhira K, Shibata N, Hattori T, Sameshima T, Sano O, Koyama R, Imaeda Y, Nara H, Cho N, Naito M. Ohoka N, et al. Among authors: nara h. J Biol Chem. 2018 May 4;293(18):6776-6790. doi: 10.1074/jbc.RA117.001091. Epub 2018 Mar 15. J Biol Chem. 2018. PMID: 29545311 Free PMC article.
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).
Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, Ujikawa O, Shimokawa K, Sano O, Koyama R, Fujita H, Teratani M, Matsumoto H, Imaeda Y, Nara H, Cho N, Naito M. Ohoka N, et al. Among authors: nara h. J Biol Chem. 2017 Mar 17;292(11):4556-4570. doi: 10.1074/jbc.M116.768853. Epub 2017 Feb 2. J Biol Chem. 2017. PMID: 28154167 Free PMC article.
Second-Generation AUTACs for Targeted Autophagic Degradation.
Takahashi D, Ora T, Sasaki S, Ishii N, Tanaka T, Matsuda T, Ikeda M, Moriyama J, Cho N, Nara H, Maezaki H, Kamaura M, Shimokawa K, Arimoto H. Takahashi D, et al. Among authors: nara h. J Med Chem. 2023 Sep 14;66(17):12342-12372. doi: 10.1021/acs.jmedchem.3c00861. Epub 2023 Aug 17. J Med Chem. 2023. PMID: 37589438
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
Nara H, Kaieda A, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M. Nara H, et al. J Med Chem. 2017 Jan 26;60(2):608-626. doi: 10.1021/acs.jmedchem.6b01007. Epub 2017 Jan 9. J Med Chem. 2017. PMID: 27966948
141 results