Rainka MP - Search Results

1

Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.

Yu T, Zhang Y, Kerekes AD, Tagat JR, Doll RJ, Xiao Y, Esposite S, Hruza A, Belanger DB, Voss M, Rainka MP, Basso A, Liu M, Liang L, Sui N, Prelusky D, Rindgen D, Zhang L. Yu T, et al. Among authors: rainka mp. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403. doi: 10.1016/j.bmcl.2018.02.037. Epub 2018 Feb 23. Bioorg Med Chem Lett. 2018. PMID: 29545102

2

Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Belanger DB, Williams MJ, Curran PJ, Mandal AK, Meng Z, Rainka MP, Yu T, Shih NY, Siddiqui MA, Liu M, Tevar S, Lee S, Liang L, Gray K, Yaremko B, Jones J, Smith EB, Prelusky DB, Basso AD. Belanger DB, et al. Among authors: rainka mp. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. doi: 10.1016/j.bmcl.2010.08.140. Epub 2010 Sep 18. Bioorg Med Chem Lett. 2010. PMID: 20855207

3

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

Voss ME, Rainka MP, Fleming M, Peterson LH, Belanger DB, Siddiqui MA, Hruza A, Voigt J, Gray K, Basso AD. Voss ME, et al. Among authors: rainka mp. Bioorg Med Chem Lett. 2012 May 15;22(10):3544-9. doi: 10.1016/j.bmcl.2012.03.051. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22503250

4

Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.

Trova MP, Barnes KD, Alicea L, Benanti T, Bielaska M, Bilotta J, Bliss B, Duong TN, Haydar S, Herr RJ, Hui Y, Johnson M, Lehman JM, Peace D, Rainka M, Snider P, Salamone S, Tregay S, Zheng X, Friedrich TD. Trova MP, et al. Among authors: rainka m. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6613-7. doi: 10.1016/j.bmcl.2009.10.011. Epub 2009 Oct 12. Bioorg Med Chem Lett. 2009. PMID: 19854650

5

A highly active Suzuki catalyst for the synthesis of sterically hindered biaryls: novel ligand coordination.

Yin J, Rainka MP, Zhang XX, Buchwald SL. Yin J, et al. Among authors: rainka mp. J Am Chem Soc. 2002 Feb 20;124(7):1162-3. doi: 10.1021/ja017082r. J Am Chem Soc. 2002. PMID: 11841272

6

Copper-catalyzed asymmetric conjugate reduction as a route to novel beta-azaheterocyclic acid derivatives.

Rainka MP, Aye Y, Buchwald SL. Rainka MP, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5821-3. doi: 10.1073/pnas.0307764101. Epub 2004 Apr 5. Proc Natl Acad Sci U S A. 2004. PMID: 15067136 Free PMC article.

7

An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates.

Rutherford JL, Rainka MP, Buchwald SL. Rutherford JL, et al. Among authors: rainka mp. J Am Chem Soc. 2002 Dec 25;124(51):15168-9. doi: 10.1021/ja0288993. J Am Chem Soc. 2002. PMID: 12487580

8

Dynamic kinetic resolution of alpha,beta-unsaturated lactones through asymmetric copper-catalyzed conjugate reduction: application to the total synthesis of eupomatilone-3.

Rainka MP, Milne JE, Buchwald SL. Rainka MP, et al. Angew Chem Int Ed Engl. 2005 Sep 26;44(38):6177-80. doi: 10.1002/anie.200501890. Angew Chem Int Ed Engl. 2005. PMID: 16130153 No abstract available.

9

Highly selective electrocatalytic dehydrogenation at low applied potential catalyzed by an Ir organometallic complex.

Bonitatibus PJ Jr, Rainka MP, Peters AJ, Simone DL, Doherty MD. Bonitatibus PJ Jr, et al. Among authors: rainka mp. Chem Commun (Camb). 2013 Nov 21;49(90):10581-3. doi: 10.1039/c3cc46051g. Chem Commun (Camb). 2013. PMID: 24091876

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