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Page 1
Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option.
Clausznitzer D, Pichardo-Almarza C, Relo AL, van Bergeijk J, van der Kam E, Laplanche L, Benson N, Nijsen M. Clausznitzer D, et al. Among authors: nijsen m. CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):759-770. doi: 10.1002/psp4.12351. Epub 2018 Oct 8. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30207429 Free PMC article.
5-sulfonyl-benzimidazoles as selective CB2 agonists-part 2.
Gijsen HJ, De Cleyn MA, Surkyn M, Van Lommen GR, Verbist BM, Nijsen MJ, Meert T, Wauwe JV, Aerssens J. Gijsen HJ, et al. Among authors: nijsen mj. Bioorg Med Chem Lett. 2012 Jan 1;22(1):547-52. doi: 10.1016/j.bmcl.2011.10.091. Epub 2011 Nov 6. Bioorg Med Chem Lett. 2012. PMID: 22130134
5-Sulfonyl-benzimidazoles as selective CB2 agonists.
Verbist BM, De Cleyn MA, Surkyn M, Fraiponts E, Aerssens J, Nijsen MJ, Gijsen HJ. Verbist BM, et al. Among authors: nijsen mj. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2574-9. doi: 10.1016/j.bmcl.2008.03.048. Epub 2008 Mar 20. Bioorg Med Chem Lett. 2008. PMID: 18394887
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME. Nijsen MJMA, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29349875 Free PMC article. Review.
A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins.
Kierzek AM, Hickling TP, Figueroa I, Kalvass JC, Nijsen M, Mohan K, Veldman GM, Yamada A, Sayama H, Yokoo S, Gulati A, Dhanikula RS, Gokemeijer J, Leil TA, Thalhauser CJ, Giorgi M, Swat MJ, Chelliah V, Small BG, Benson N, Walker M, Gadkar K, Quarmby V, Deng R, Ferrante A, Dickinson GL, Van Der Walt JS, Zhou L, Chen X, Jones HM, Narula J, Tourdot S, Lavé T, Ribba B, van der Graaf PH. Kierzek AM, et al. Among authors: nijsen m. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):773-776. doi: 10.1002/psp4.12465. Epub 2019 Oct 8. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31529677 Free PMC article. No abstract available.
Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.
Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, Jones RDO, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, Nijsen MJMA, Chan JR. Bradshaw EL, et al. Among authors: nijsen mjma. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):777-791. doi: 10.1002/psp4.12463. Epub 2019 Oct 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31535440 Free PMC article.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Chelliah V, Lazarou G, Bhatnagar S, Gibbs JP, Nijsen M, Ray A, Stoll B, Thompson RA, Gulati A, Soukharev S, Yamada A, Weddell J, Sayama H, Oishi M, Wittemer-Rump S, Patel C, Niederalt C, Burghaus R, Scheerans C, Lippert J, Kabilan S, Kareva I, Belousova N, Rolfe A, Zutshi A, Chenel M, Venezia F, Fouliard S, Oberwittler H, Scholer-Dahirel A, Lelievre H, Bottino D, Collins SC, Nguyen HQ, Wang H, Yoneyama T, Zhu AZX, van der Graaf PH, Kierzek AM. Chelliah V, et al. Among authors: nijsen m. Clin Pharmacol Ther. 2021 Mar;109(3):605-618. doi: 10.1002/cpt.1987. Epub 2020 Aug 14. Clin Pharmacol Ther. 2021. PMID: 32686076 Free PMC article. Review.
35 results