Chen Y - Search Results

1

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.

Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W, Zhou R. Huang Y, et al. Among authors: chen y. EMBO Mol Med. 2018 Apr;10(4):e8689. doi: 10.15252/emmm.201708689. EMBO Mol Med. 2018. PMID: 29531021 Free PMC article.

2

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.

Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R. Jiang H, et al. Among authors: chen y. J Exp Med. 2017 Nov 6;214(11):3219-3238. doi: 10.1084/jem.20171419. Epub 2017 Oct 11. J Exp Med. 2017. PMID: 29021150 Free PMC article.

3

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.

He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X, Jiang W, Zhou R. He H, et al. Among authors: chen y. Nat Commun. 2018 Jun 29;9(1):2550. doi: 10.1038/s41467-018-04947-6. Nat Commun. 2018. PMID: 29959312 Free PMC article.

4

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors.

Chen Y, He H, Jiang H, Li L, Hu Z, Huang H, Xu Q, Zhou R, Deng X. Chen Y, et al. Bioorg Med Chem Lett. 2020 Apr 1;30(7):127021. doi: 10.1016/j.bmcl.2020.127021. Epub 2020 Feb 6. Bioorg Med Chem Lett. 2020. PMID: 32057583

5

Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome.

Zheng X, Hou Y, He H, Chen Y, Zhou R, Wang X, Gong T, Jiang W. Zheng X, et al. Among authors: chen y. Cell Mol Immunol. 2021 Oct;18(10):2422-2430. doi: 10.1038/s41423-020-00545-z. Epub 2020 Sep 11. Cell Mol Immunol. 2021. PMID: 32917982 Free PMC article.

6

RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor.

Chen Y, He H, Lin B, Chen Y, Deng X, Jiang W, Zhou R. Chen Y, et al. Cell Mol Immunol. 2021 Jun;18(6):1425-1436. doi: 10.1038/s41423-021-00683-y. Epub 2021 May 10. Cell Mol Immunol. 2021. PMID: 33972740 Free PMC article.

7

Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.

Zhou XL, Chen Y, Zeng QY, Ruan ZR, Fang P, Wang ED. Zhou XL, et al. Among authors: chen y. Nucleic Acids Res. 2019 Sep 19;47(16):8662-8674. doi: 10.1093/nar/gkz588. Nucleic Acids Res. 2019. PMID: 31287872 Free PMC article.

8

A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

Chen Y, Ruan ZR, Wang Y, Huang Q, Xue MQ, Zhou XL, Wang ED. Chen Y, et al. Nucleic Acids Res. 2018 Apr 20;46(7):3643-3656. doi: 10.1093/nar/gky211. Nucleic Acids Res. 2018. PMID: 29579307 Free PMC article.

9

miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release.

Lu SY, Fu CL, Liang L, Yang B, Shen W, Wang QW, Chen Y, Chen YF, Liu YN, Zhu L, Zhao J, Shi W, Mi S, Yao J. Lu SY, et al. Among authors: chen yf, chen y. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2021770118. doi: 10.1073/pnas.2021770118. Proc Natl Acad Sci U S A. 2021. PMID: 33782126 Free PMC article.

10

Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.

Chen Y, Wang YH, Zheng Y, Li M, Wang B, Wang QW, Fu CL, Liu YN, Li X, Yao J. Chen Y, et al. Cell Rep. 2021 Mar 16;34(11):108842. doi: 10.1016/j.celrep.2021.108842. Cell Rep. 2021. PMID: 33730593 Free article.

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