Boot-Handford RP - Search Results

1

Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.

Forouhan M, Mori K, Boot-Handford RP. Forouhan M, et al. Among authors: boot handford rp. Matrix Biol. 2018 Sep;70:50-71. doi: 10.1016/j.matbio.2018.03.004. Epub 2018 Mar 6. Matrix Biol. 2018. PMID: 29522813 Free PMC article.

2

Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.

Mullan LA, Mularczyk EJ, Kung LH, Forouhan M, Wragg JM, Goodacre R, Bateman JF, Swanton E, Briggs MD, Boot-Handford RP. Mullan LA, et al. J Clin Invest. 2017 Oct 2;127(10):3861-3865. doi: 10.1172/JCI93094. Epub 2017 Sep 18. J Clin Invest. 2017. PMID: 28920921 Free PMC article.

3

Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene.

Forouhan M, Sonntag S, Boot-Handford RP. Forouhan M, et al. Among authors: boot handford rp. Hum Mol Genet. 2018 Nov 15;27(22):3840-3853. doi: 10.1093/hmg/ddy253. Hum Mol Genet. 2018. PMID: 30010889 Free PMC article.

4

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.

Kung LHW, Mullan L, Soul J, Wang P, Mori K, Bateman JF, Briggs MD, Boot-Handford RP. Kung LHW, et al. Among authors: boot handford rp. Arthritis Res Ther. 2019 Sep 11;21(1):206. doi: 10.1186/s13075-019-1988-6. Arthritis Res Ther. 2019. PMID: 31511053 Free PMC article.

5

Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.

Kung LH, Rajpar MH, Briggs MD, Boot-Handford RP. Kung LH, et al. J Histochem Cytochem. 2012 Oct;60(10):734-48. doi: 10.1369/0022155412458436. Epub 2012 Aug 1. J Histochem Cytochem. 2012. PMID: 22859705 Free PMC article.

6

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.

Hartley CL, Edwards S, Mullan L, Bell PA, Fresquet M, Boot-Handford RP, Briggs MD. Hartley CL, et al. Hum Mol Genet. 2013 Dec 20;22(25):5262-75. doi: 10.1093/hmg/ddt383. Epub 2013 Aug 15. Hum Mol Genet. 2013. PMID: 23956175 Free PMC article.

7

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Gualeni B, Rajpar MH, Kellogg A, Bell PA, Arvan P, Boot-Handford RP, Briggs MD. Gualeni B, et al. Dis Model Mech. 2013 Nov;6(6):1414-25. doi: 10.1242/dmm.013342. Epub 2013 Sep 12. Dis Model Mech. 2013. PMID: 24046357 Free PMC article.

8

Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.

Piróg KA, Irman A, Young S, Halai P, Bell PA, Boot-Handford RP, Briggs MD. Piróg KA, et al. PLoS One. 2014 Feb 18;9(2):e85145. doi: 10.1371/journal.pone.0085145. eCollection 2014. PLoS One. 2014. PMID: 24558358 Free PMC article.

9

Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.

Kung LH, Rajpar MH, Preziosi R, Briggs MD, Boot-Handford RP. Kung LH, et al. PLoS One. 2015 Feb 18;10(2):e0117016. doi: 10.1371/journal.pone.0117016. eCollection 2015. PLoS One. 2015. PMID: 25693198 Free PMC article.

10

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease.

Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF. Cameron TL, et al. PLoS Genet. 2015 Sep 15;11(9):e1005505. doi: 10.1371/journal.pgen.1005505. eCollection 2015 Sep. PLoS Genet. 2015. PMID: 26372225 Free PMC article.

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