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Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L. Infante P, et al. Among authors: gulino a. Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0. Nat Commun. 2018. PMID: 29515120 Free PMC article.
Hedgehog signalling in colon cancer and stem cells.
Gulino A, Ferretti E, De Smaele E. Gulino A, et al. EMBO Mol Med. 2009 Sep;1(6-7):300-2. doi: 10.1002/emmm.200900042. EMBO Mol Med. 2009. PMID: 20049733 Free PMC article.
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L. Bufalieri F, et al. Among authors: gulino a. Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0. Nat Commun. 2019. PMID: 31341163 Free PMC article.
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.
Mazzà D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, Antonucci L, Po A, De Smaele E, Ferretti E, Capalbo C, Bellavia D, Canettieri G, Giannini G, Screpanti I, Gulino A, Di Marcotullio L. Mazzà D, et al. Among authors: gulino a. Cell Death Differ. 2013 Dec;20(12):1688-97. doi: 10.1038/cdd.2013.120. Epub 2013 Sep 6. Cell Death Differ. 2013. PMID: 24013724 Free PMC article.
421 results