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Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.
Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A. Selkrig J, et al. Among authors: sigismondo g. Nat Microbiol. 2020 Sep;5(9):1119-1133. doi: 10.1038/s41564-020-0736-7. Epub 2020 Jun 8. Nat Microbiol. 2020. PMID: 32514074 Free PMC article.
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.
Bakr A, Hey J, Sigismondo G, Liu CS, Sadik A, Goyal A, Cross A, Iyer RL, Müller P, Trauernicht M, Breuer K, Lutsik P, Opitz CA, Krijgsveld J, Weichenhan D, Plass C, Popanda O, Schmezer P. Bakr A, et al. Among authors: sigismondo g. Nucleic Acids Res. 2021 Nov 18;49(20):11666-11689. doi: 10.1093/nar/gkab964. Nucleic Acids Res. 2021. PMID: 34718742 Free PMC article.
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.
Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. Ecker J, et al. Among authors: sigismondo g. Neuro Oncol. 2021 Feb 25;23(2):226-239. doi: 10.1093/neuonc/noaa191. Neuro Oncol. 2021. PMID: 32822486 Free PMC article.
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Zanconato F, et al. Among authors: sigismondo g. Nat Med. 2018 Oct;24(10):1599-1610. doi: 10.1038/s41591-018-0158-8. Epub 2018 Sep 17. Nat Med. 2018. PMID: 30224758 Free PMC article.
24 results