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Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD. Escudero S, et al. Among authors: haigis mc. Mol Cell. 2018 Mar 1;69(5):729-743.e7. doi: 10.1016/j.molcel.2018.02.005. Mol Cell. 2018. PMID: 29499131 Free PMC article.
Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.
Cable J, Rathmell JC, Pearce EL, Ho PC, Haigis MC, Mamedov MR, Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O'Neill LAJ, Perry RJ, Brenner D. Cable J, et al. Among authors: haigis mc. Ann N Y Acad Sci. 2023 May;1523(1):38-50. doi: 10.1111/nyas.14976. Epub 2023 Mar 24. Ann N Y Acad Sci. 2023. PMID: 36960914 Free PMC article.
Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells.
Xiao W, Shrimali N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Xiao W, et al. Among authors: haigis mc. bioRxiv [Preprint]. 2024 May 30:2024.05.29.595538. doi: 10.1101/2024.05.29.595538. bioRxiv. 2024. Update in: Nat Metab. 2024 Nov;6(11):2138-2156. doi: 10.1038/s42255-024-01150-4 PMID: 38853866 Free PMC article. Updated. Preprint.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. Laurent G, et al. Among authors: haigis mc. Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012. Mol Cell. 2013. PMID: 23746352 Free PMC article.
Mitochondria and Cancer.
Vyas S, Zaganjor E, Haigis MC. Vyas S, et al. Among authors: haigis mc. Cell. 2016 Jul 28;166(3):555-566. doi: 10.1016/j.cell.2016.07.002. Cell. 2016. PMID: 27471965 Free PMC article. Review.
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC. German NJ, et al. Among authors: haigis mc. Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014. Mol Cell. 2016. PMID: 27635760 Free PMC article.
SIRT4 Is a Regulator of Insulin Secretion.
Zaganjor E, Vyas S, Haigis MC. Zaganjor E, et al. Among authors: haigis mc. Cell Chem Biol. 2017 Jun 22;24(6):656-658. doi: 10.1016/j.chembiol.2017.06.002. Cell Chem Biol. 2017. PMID: 28644956 Free article.
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Gonzalez Herrera KN, et al. Among authors: haigis mc. Cell Rep. 2018 Feb 20;22(8):1945-1955. doi: 10.1016/j.celrep.2018.01.076. Cell Rep. 2018. PMID: 29466723 Free PMC article.
133 results