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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.
Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M. Ferrucci V, et al. Among authors: tirone f. Brain. 2018 May 1;141(5):1300-1319. doi: 10.1093/brain/awy039. Brain. 2018. PMID: 29490009
Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells.
Ceccarelli M, Rossi S, Bonaventura F, Massari R, D'Elia A, Soluri A, Micheli L, D'Andrea G, Mancini B, Raspa M, Scavizzi F, Alaggio R, Del Bufalo F, Miele E, Carai A, Mastronuzzi A, Tirone F. Ceccarelli M, et al. Among authors: tirone f. Brain Pathol. 2025 Jan;35(1):e13283. doi: 10.1111/bpa.13283. Epub 2024 Jun 30. Brain Pathol. 2025. PMID: 38946128 Free PMC article.
Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model.
Presutti D, Ceccarelli M, Micheli L, Papoff G, Santini S, Samperna S, Lalli C, Zentilin L, Ruberti G, Tirone F. Presutti D, et al. Among authors: tirone f. PLoS One. 2018 Mar 14;13(3):e0194206. doi: 10.1371/journal.pone.0194206. eCollection 2018. PLoS One. 2018. PMID: 29538458 Free PMC article.
Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.
Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F. Farioli-Vecchioli S, et al. Among authors: tirone f. J Neurosci. 2012 Oct 31;32(44):15547-64. doi: 10.1523/JNEUROSCI.0412-12.2012. J Neurosci. 2012. PMID: 23115191 Free PMC article.
85 results