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When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.
Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S. Bradbury ARM, et al. Among authors: trinklein nd. MAbs. 2018 May/Jun;10(4):539-546. doi: 10.1080/19420862.2018.1445456. Epub 2018 Mar 29. MAbs. 2018. PMID: 29485921 Free PMC article.
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.
Harris KE, Aldred SF, Davison LM, Ogana HAN, Boudreau A, Brüggemann M, Osborn M, Ma B, Buelow B, Clarke SC, Dang KH, Iyer S, Jorgensen B, Pham DT, Pratap PP, Rangaswamy US, Schellenberger U, van Schooten WC, Ugamraj HS, Vafa O, Buelow R, Trinklein ND. Harris KE, et al. Among authors: trinklein nd. Front Immunol. 2018 Apr 24;9:889. doi: 10.3389/fimmu.2018.00889. eCollection 2018. Front Immunol. 2018. PMID: 29740455 Free PMC article.
Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122.
Boutz DR, Collins PJ, Suresh U, Lu M, Ramírez CM, Fernández-Hernando C, Huang Y, Abreu Rde S, Le SY, Shapiro BA, Liu AM, Luk JM, Aldred SF, Trinklein ND, Marcotte EM, Penalva LO. Boutz DR, et al. Among authors: trinklein nd. J Biol Chem. 2011 May 20;286(20):18066-78. doi: 10.1074/jbc.M110.196451. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402708 Free PMC article.
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies.
Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. Trinklein ND, et al. MAbs. 2019 May/Jun;11(4):639-652. doi: 10.1080/19420862.2019.1574521. Epub 2019 Feb 20. MAbs. 2019. PMID: 30698484 Free PMC article.
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL.
Malik-Chaudhry HK, Prabhakar K, Ugamraj HS, Boudreau AA, Buelow B, Dang K, Davison LM, Harris KE, Jorgensen B, Ogana H, Pham D, Schellenberger U, Van Schooten W, Buelow R, Iyer S, Trinklein ND, Rangaswamy US. Malik-Chaudhry HK, et al. Among authors: trinklein nd. MAbs. 2021 Jan-Dec;13(1):1890411. doi: 10.1080/19420862.2021.1890411. MAbs. 2021. PMID: 33818299 Free PMC article.
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.
Clarke SC, Ma B, Trinklein ND, Schellenberger U, Osborn MJ, Ouisse LH, Boudreau A, Davison LM, Harris KE, Ugamraj HS, Balasubramani A, Dang KH, Jorgensen B, Ogana HAN, Pham DT, Pratap PP, Sankaran P, Anegon I, van Schooten WC, Brüggemann M, Buelow R, Force Aldred S. Clarke SC, et al. Among authors: trinklein nd. Front Immunol. 2019 Jan 7;9:3037. doi: 10.3389/fimmu.2018.03037. eCollection 2018. Front Immunol. 2019. PMID: 30666250 Free PMC article.
35 results