Spencer J - Search Results

1

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

Hinchliffe P, Tanner CA, Krismanich AP, Labbé G, Goodfellow VJ, Marrone L, Desoky AY, Calvopiña K, Whittle EE, Zeng F, Avison MB, Bols NC, Siemann S, Spencer J, Dmitrienko GI. Hinchliffe P, et al. Among authors: spencer j. Biochemistry. 2018 Mar 27;57(12):1880-1892. doi: 10.1021/acs.biochem.7b01299. Epub 2018 Mar 9. Biochemistry. 2018. PMID: 29485857 Free PMC article.

2

Domain behavior during the folding of a thermostable phosphoglycerate kinase.

Parker MJ, Spencer J, Jackson GS, Burston SG, Hosszu LL, Craven CJ, Waltho JP, Clarke AR. Parker MJ, et al. Among authors: spencer j. Biochemistry. 1996 Dec 10;35(49):15740-52. doi: 10.1021/bi961330s. Biochemistry. 1996. PMID: 8961937

3

Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ. Spencer J, et al. J Am Chem Soc. 2005 Oct 19;127(41):14439-44. doi: 10.1021/ja0536062. J Am Chem Soc. 2005. PMID: 16218639

4

A new approach to the inhibition of metallo-beta-lactamases.

Spencer J, Walsh TR. Spencer J, et al. Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1022-6. doi: 10.1002/anie.200502984. Angew Chem Int Ed Engl. 2006. PMID: 16404761 Review. No abstract available.

5

Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.

Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J. Murphy TA, et al. Among authors: spencer j. J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23. J Mol Biol. 2006. PMID: 16460758

6

Structural basis for the role of Asp-120 in metallo-beta-lactamases.

Crisp J, Conners R, Garrity JD, Carenbauer AL, Crowder MW, Spencer J. Crisp J, et al. Among authors: spencer j. Biochemistry. 2007 Sep 18;46(37):10664-74. doi: 10.1021/bi700707u. Epub 2007 Aug 23. Biochemistry. 2007. PMID: 17715946

7

The basis for carbapenem hydrolysis by class A β-lactamases: a combined investigation using crystallography and simulations.

Fonseca F, Chudyk EI, van der Kamp MW, Correia A, Mulholland AJ, Spencer J. Fonseca F, et al. Among authors: spencer j. J Am Chem Soc. 2012 Nov 7;134(44):18275-85. doi: 10.1021/ja304460j. Epub 2012 Oct 29. J Am Chem Soc. 2012. PMID: 23030300

8

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: spencer j. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.

9

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Brem J, et al. Among authors: spencer j. Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17. Nat Chem. 2014. PMID: 25411887

10

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.

Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris ME, Vila AJ, Spencer J, Bonomo RA. Mojica MF, et al. Among authors: spencer j. Biochemistry. 2015 May 26;54(20):3183-96. doi: 10.1021/acs.biochem.5b00106. Epub 2015 May 12. Biochemistry. 2015. PMID: 25915520 Free PMC article.

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